| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Dynamic immune response and influencing factors in COVID-19 patients with non-alcoholic fatty liver disease: A cohort study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Pan Yan, Rui Li, Xiao-Yan Yuan, Yong Wang, Li-Juan Lan, Xiao-Ping Yu and Da-Feng Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chengdu Science and Technology Bureau |
2021-YF05-00536-SN |
|
| Corresponding Author |
Da-Feng Liu, The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, No.377 Jingming Road, Jinjiang District, Chengdu 610060, Sichuan Province, China. ldf312@126.com |
| Key Words |
COVID-19; Non-alcoholic fatty liver disease; Lymphocyte subsets; Dynamic immune response; Risk factors |
| Core Tip |
This study reveals that coronavirus disease 2019 patients with non-alcoholic fatty liver disease (NAFLD) exhibit prolonged immune imbalance. Key risk factors - including age ≥ 60 years, significant liver fibrosis, multimorbidity (≥ 3 conditions), obesity, elevated liver enzymes, elevated low-density lipoprotein cholesterol and hemoglobin A1c - worsen immune imbalance. Notably, even lean NAFLD patients show persistent immune disturbances. These findings highlight the need for tailored clinical monitoring in coronavirus disease 2019-NAFLD patients, particularly for older adults, those with metabolic dysfunction, or advanced liver disease, to mitigate long-term immunological complications. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Yan P, Li R, Yuan XY, Wang Y, Lan LJ, Yu XP, Liu DF. Dynamic immune response and influencing factors in COVID-19 patients with non-alcoholic fatty liver disease: A cohort study. World J Hepatol 2026; 18(2): 113004 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/113004.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.113004 |
