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Articles Published Processes
2/2/2026 7:26:03 AM | Browse: 1 | Download: 5
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Received |
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2025-08-13 01:51 |
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Peer-Review Started |
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2025-08-13 01:51 |
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First Decision by Editorial Office Director |
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2025-09-08 10:12 |
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Return for Revision |
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2025-09-08 10:12 |
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Revised |
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2025-10-23 11:55 |
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Publication Fee Transferred |
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2025-10-28 03:22 |
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Second Decision by Editor |
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2025-12-11 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-11 09:22 |
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Articles in Press |
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2025-12-11 09:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-26 02:41 |
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Publish the Manuscript Online |
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2026-02-02 07:26 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peng-Chun Yang, Chun-Yan Xiao, Jing Wang, Cai-Hua Yan, Qi-Yi Li, Shi-Yu Li, Jian Li, Li-Jing Zhang and Chi-Bing Dai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research Project of Hubei Provincial Health Commission |
WJ2021F060 |
| Open Fund of the Basic and Clinical Pathology Research Center of Three Gorges University |
RHKFBL2022-13 |
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| Corresponding Author |
Chi-Bing Dai, Department of Gastroenterology, Affiliated Renhe Hospital of China Three Gorges University, No. 435 Yiling Road, Yichang 443001, Hubei Province, China. dchibing@126.com |
| Key Words |
High-fat diet; Bifidobacterium; Deoxycholic acid; Macrophage polarization; Microbiota; Intestinal inflammation |
| Core Tip |
A high-fat diet increases fecal deoxycholic acid (DCA), inducing M1 macrophage polarization and intestinal inflammation. Bifidobacterium mitigates this by reducing the production of DCA, inhibiting M1 polarization, and partially restoring gut microbiota balance. Hence, they can be employed for treating high-fat diet-associated colitis. This study aims to investigate changes in intestinal flora, fecal DCA levels, and cytokine profiles. |
| Publish Date |
2026-02-02 07:26 |
| Citation |
Yang PC, Xiao CY, Wang J, Yan CH, Li QY, Li SY, Li J, Zhang LJ, Dai CB. Effects and mechanism of Bifidobacterium on intestinal inflammation resulting from deoxycholic acid-induced M1 polarization of macrophages. World J Gastroenterol 2026; 32(6): 113010 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i6/113010.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i6.113010 |
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