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Articles Published Processes
1/28/2026 9:23:40 AM | Browse: 1 | Download: 0
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Received |
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2025-08-18 08:02 |
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Peer-Review Started |
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2025-08-18 08:02 |
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First Decision by Editorial Office Director |
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2025-09-23 09:49 |
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Return for Revision |
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2025-09-23 09:49 |
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Revised |
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2025-10-15 14:11 |
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Publication Fee Transferred |
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2025-10-17 01:53 |
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Second Decision by Editor |
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2025-12-08 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-08 06:50 |
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Articles in Press |
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2025-12-08 06:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-20 00:30 |
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Publish the Manuscript Online |
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2026-01-28 09:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tian Xu, Wei-Xin Hou, Sun-Ting Yang, Yu-Pei Shao, Jing Wang, Tao-Tao Han and Jing-Nan Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82405050 |
| National Natural Science Foundation of China |
8227034002 |
| National Natural Science Foundation of China |
8210035244 |
| Fundamental Research Funds for the Central Universities, China |
3332024017 |
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| Corresponding Author |
Jing-Nan Li, Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. jnli2020@126.com |
| Key Words |
Danggui-Baishao herb pair; Benzoylpaeoniflorin; Ulcerative colitis; Wnt/β-catenin pathway; Intestinal barrier; Gut microbiota; Bile acids |
| Core Tip |
The Danggui-Baishao herb pair has shown definite anti-colitis effects in traditional Chinese medicine. By detecting the active ingredients of the herb pair and using transcriptome sequencing for mechanism prediction, our results show that the herb pair protects against colitis by activating the Wnt/β-catenin pathway in vivo, yet this effect is diminished by the β-catenin antagonist ICG-001. Through metabolomics, 16S rRNA, and metagenomic further revealed that the herb pair regulates bile acids metabolism and gut microbiota composition. Finally, molecular docking revealed that benzoylpaeoniflorin has a structural basis for binding to β-catenin. Benzoylpaeoniflorin can activating the Wnt/β-catenin pathway in vitro and diminished by the ICG-001. This study provides experimental evidence for research on anti-colitis drugs. |
| Publish Date |
2026-01-28 09:23 |
| Citation |
Xu T, Hou WX, Yang ST, Shao YP, Wang J, Han TT, Li JN. Danggui-Baishao herb pair protects against dextran sulfate sodium-induced colitis by modulating the Wnt/β-catenin pathway. World J Gastroenterol 2026; 32(5): 113024 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i5/113024.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i5.113024 |
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