Publication Name	World Journal of Gastroenterology
Manuscript ID	11304
Country	Germany

Received	2014-05-14 20:46
Peer-Review Started	2014-05-14 21:36
To Make the First Decision	2014-06-27 17:47
Return for Revision	2014-07-02 15:46
Revised	2014-07-20 22:59
Second Decision	2014-08-28 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-08-28 10:34
Articles in Press	2014-08-28 10:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-19 13:59
Publish the Manuscript Online	2015-01-07 11:07

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Florian Kuehn, Ernst Klar, Anja Bliemeister and Michael Linnebacher
Funding Agency and Grant Number	Funding Agency Grant Number University of Rostock (FORUN program)
Corresponding Author	Michael Linnebacher, PhD, Department of General, Thoracic, Vascular and Transplantation Surgery, Molecular Oncology and Immunotherapy, University of Rostock, Schillingallee 35, 18057 Rostock, Germany. michael.linnebacher@med.uni-rostock.de
Key Words	Microsatellite-instability; Inflammatory bowel diseas; Frameshift peptides; Immune response; Thiopurine
Core Tip	Oxidative stress resulting from chronic inflammation is likely to relax the mismatch repair (MMR) system and to cause DNA damage. On the other hand thiopurine treatment positively selects for cell variants with defective MMR system. inflammatory bowel disease (IBD) patients are often exposed to both factors, hypothetically resulting in an increased number of frameshift mutations. This study shows an increased immune response towards microsatellite-instability-induced frameshift-peptides (FSPs) in patients with IBD. It is the first report which provides functional evidence of FSP expression under non- but possible pre-neoplastic conditions. These findings have potential implications for screening, diagnosis as well as clinical management of IBD patients.
Publish Date	2015-01-07 11:07
Citation	Kuehn F, Klar E, Bliemeister A, Linnebacher M. Reactivity against microsatellite instability-induced frameshift mutations in patients with inflammatory bowel disease. World J Gastroenterol 2015; 21(1): 221-228
URL	http://www.wjgnet.com/1007-9327/full/v21/i1/221.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i1.221

Full Article (PDF)	WJG-21-221.pdf
Full Article (Word)	WJG-21-221.doc
Manuscript File	11304-Review.doc
Answering Reviewers	11304-Answering reviewers.pdf
Copyright License Agreement	11304-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	11304-Language certificate.pdf
Peer-review Report	11304-Peer review.pdf
Scientific Misconduct Check	11304-CorssCheck.jpg
Scientific Editor Work List	11304-Scientific editor work list.pdf