| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Meta-analysis of the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for locally advanced rectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Xing Yan, Hong-Qin Yuan, Ze-Yi Xiong, Li-Juan Qin, Juan Wu, Juan He, Jie Mu, Jia Li and Ning Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Start-up Fund for Doctor's Scientific Research in Shanxi Cancer Hospital |
Dr202314 |
| Natural Exploration Category of Shanxi Basic Research Plan |
202203021221284 |
|
| Corresponding Author |
Ning Li, Department of Radiation Oncology, Shanxi Province Cancer Hospital Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences Cancer Hospital Affiliated to Shanxi Medical UniversityCancer Hospital Affiliated to Shanxi Medical University, No. 3, Zhigongxin Street, Taiyuan 030013, Shanxi Province, China. lee_ak@163.com |
| Key Words |
Immunotherapy; Defective mismatch repair; Meta-analysis; Locally advanced rectal cancer; Proficient mismatch repair; Microsatellite stability |
| Core Tip |
Immunotherapy is an approved treatment for metastatic rectal cancer in patients with defective mismatch repair (MMR). Neoadjuvant chemotherapy combined with immunotherapy can benefit patients who have locally advanced rectal cancer (LARC) with proficient MMR (pMMR)/microsatellite stability (MSS). Through a meta-analysis with 15 publications included, the results of our meta-analysis showed that neoadjuvant immunotherapy combined with radiotherapy and chemotherapy can improve the clinical remission rate (major pathologic response, clinical complete response, and pathologic complete response) of patients with LARC, especially for those with pMMR/MSS, and this treatment did not increase the incidence of postoperative complications and adverse reactions. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
Yan WX, Yuan HQ, Xiong ZY, Qin LJ, Wu J, He J, Mu J, Li J, Li N. Meta-analysis of the efficacy of neoadjuvant immunotherapy combined with radiotherapy and chemotherapy for locally advanced rectal cancer. World J Gastrointest Oncol 2025; 17(11): 113048 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/113048.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.113048 |
