| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nan Zhang, Yi Wang, Shuang-Shuang Fang, Ming Han, Qin-Wei Zheng, Ying-Ying Zhu, Meng-Yuan Zhang, Jing-Jing Li, Lin-Xuan Cui, Jin-Li Tian, Yu-Hai Deng, Sheng-Liang Zhu, Hong-Mei Ni, Li Zhou, Guang-Liang Zuo, Tian-Sheng Huang, Qi Liao, Xiu-Qing Li, Ying-Ying Shang, Yong-Jun Wang, Yun Tian, Ling-Yu Ge, Hai-Qiong Han, Wei-Min Hu, Yi Jiang, Ya-Juan Li, Xiang Mao, Li-Hong Yang, Jun-Min Yao, Xin Zheng, Hong-Wei Wang and Sheng-Quan Fang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program Project |
No. 2024YFC3505303 |
| Flagship department construction project of Traditional Chinese Medicine and Western Medicine Collaboration of the State Administration of Traditional Chinese Medicine |
No. 2024-2027 |
| Shanghai Municipal Government’s Three-Year Action Plan for Accelerating the Inheritance and Innovation of Traditional Chinese Medicine |
No. 2025-2027-(1-1-2) |
| Zhu Sheng-Liang National Prestigious Chinese Medicine Experts Inheritance Workshop Construction Project National Traditional Chinese Medicine Human Education Letter (2022) |
No. 75 |
| Shanghai Municipal Government Three-Year Action Plan for Traditional Chinese Medicine Key Project |
No. ZY (2021-2023)-0302 |
| Shanghai Municipal Health Commission Clinical Specialties |
No. 202140171 |
| Natural Science Foundation of Shanghai Science and Technology Commission |
No. 20ZR1459300 |
| Shanghai Municipal Hospital Gastroenterology Clinical Competence Improvement and Advancement Specialist Alliance |
No. SHDC22024302 |
| Shanghai University of Traditional Chinese Medicine Affiliated Yueyang Integrated Traditional and Western Medicine, Hospital Translational Medicine Research Fund |
No. 2024YJJB14 |
| Training Program for High-caliber Talents of Clinical Research at Affiliated Hospitals of Shanghai University of Traditional Chinese Medicine |
|
|
| Corresponding Author |
Sheng-Quan Fang, Chief Physician, Professor, Department of Gastroenterology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, No. 110 Ganhe Road, Hongkou District, Shanghai 200437, China. fsq20032003@163.com |
| Key Words |
Refractory gastroesophageal reflux disease; Clinical characteristics; Risk factors; Anxiety; Multicenter Cross-sectional study |
| Core Tip |
Refractory gastroesophageal reflux disease (GERD) represents a clinically challenging subtype of GERD that remains poorly understood. This cross-sectional study examined data from 256 patients with refractory GERD and 655 patients with non-refractory GERD to identify clinical characteristics and potential risk factors. The results indicate that prolonged disease duration, anxiety, and insufficient physical activity are independent risk factors for refractory GERD. Furthermore, age, overeating, esophageal chest pain, sensation of pharyngeal obstruction, and constipation showed strong correlations with refractory GERD. These findings underscore the presence of distinct, complex pathophysiological mechanisms and clinical features in refractory GERD, along with the role of psychological factors, providing useful insights for long-term management and treatment strategies for refractory GERD. |
| Publish Date |
2025-12-03 09:10 |
| Citation |
Zhang N, Wang Y, Fang SS, Han M, Zheng QW, Zhu YY, Zhang MY, Li JJ, Cui LX, Tian JL, Deng YH, Zhu SL, Ni HM, Zhou L, Zuo GL, Huang TS, Liao Q, Li XQ, Shang YY, Wang YJ, Tian Y, Ge LY, Han HQ, Hu WM, Jiang Y, Li YJ, Mao X, Yang LH, Yao JM, Zheng X, Wang HW, Fang SQ. Clinical characteristics and risk factors of refractory gastroesophageal reflux disease: A multicenter cross-sectional study. World J Gastroenterol 2025; 31(45): 113060 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i45/113060.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i45.113060 |
