| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Observational Study |
| Article Title |
Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xiao-Fang Hou, Bo-Hui Mei, Xia Wang, Fu-Tao Zhao, Lei He, Qian-Yu Chen, Chen Zang, Chong Wang, Yu-Feng Tang, Xiao-Xin Li, Hui-Fang Zhang, Na Wang and Bing Cao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiao-Fang Hou, Department of Magnetic Resonance Imaging, The Affiliated Brain Hospital of Zhengzhou University, The Second People’s Hospital of Zhumadian, No. 51 East Section of Xuesong Road, Yicheng District, Zhumadian 463000, Henan Province, China. hxf758@126.com |
| Key Words |
Neuroimage; Comorbidity; Brain activity; Obesity; Major depression; Regional spontaneous |
| Core Tip |
This study used resting-state functional magnetic resonance imaging and regional homogeneity analysis to investigate spontaneous brain activity in patients with comorbid major depressive disorder and obesity. Significant regional homogeneity alterations were found in the left middle temporal gyrus, right cuneus, left precuneus, and left thalamus. These findings suggest shared and synergistic neurobiological mechanisms underlying major depressive disorder-obesity comorbidity and highlight potential targets, such as left middle temporal gyrus hyperactivity, for personalized interventions aimed at improving emotional regulation and food-related cue processing in affected individuals. |
| Publish Date |
2025-12-31 05:47 |
| Citation |
Hou XF, Mei BH, Wang X, Zhao FT, He L, Chen QY, Zang C, Wang C, Tang YF, Li XX, Zhang HF, Wang N, Cao B. Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study. World J Psychiatry 2026; 16(1): 113064 |
| URL |
https://www.wjgnet.com/2220-3206/full/v16/i1/113064.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v16.i1.113064 |
