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12/31/2025 5:47:45 AM | Browse: 2 | Download: 15
Publication Name World Journal of Psychiatry
Manuscript ID 113104
Country China
Received
2025-09-16 09:28
Peer-Review Started
2025-09-16 09:28
First Decision by Editorial Office Director
2025-10-11 02:50
Return for Revision
2025-10-11 02:50
Revised
2025-10-21 14:51
Publication Fee Transferred
2025-10-23 03:53
Second Decision by Editor
2025-12-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-03 08:38
Articles in Press
2025-12-03 08:38
Edit the Manuscript by Language Editor
2025-12-08 23:13
Typeset the Manuscript
2025-12-18 09:11
Publish the Manuscript Online
2025-12-31 05:47
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Retrospective Study
Article Title Risk factors and early identification markers for post-ischemic stroke anxiety and depression
Manuscript Source Unsolicited Manuscript
All Author List Jie-Dong Zhao, Song-Wang Qiu, Kai-Yan Lin, Hui-Yan Lin and Chang-Wei Yu
ORCID
Author(s) ORCID Number
Chang-Wei Yu http://orcid.org/0009-0000-3980-2391
Funding Agency and Grant Number
Corresponding Author Chang-Wei Yu, Department of Neurology, The First Affiliated Hospital of Xiamen University, No. 160 Hexiang West Road, Siming District, Xiamen 361000, Fujian Province, China. 15880284048@163.com
Key Words Ischemic stroke; Anxiety and depression; Risk factors; Biomarkers; Brain-derived neurotrophic factor
Core Tip Post-stroke anxiety and depression are common yet underrecognized complications after ischemic stroke, adversely affecting recovery and prognosis. This study integrates demographic, clinical, neuroimaging, inflammatory, and neuroendocrine indicators to identify independent risk factors and early biomarkers for post-stroke anxiety and depression. Female gender, prior mental disorders, frontal-limbic infarcts, severe stroke, and low social support were key predictors. Elevated interleukin-6, tumor necrosis factor-alpha, and cortisol, alongside reduced insulin-like growth factor-1, showed strong diagnostic value, providing a multidimensional framework for early screening and targeted intervention in high-risk patients.
Publish Date 2025-12-31 05:47
Citation

Zhao JD, Qiu SW, Lin KY, Lin HY, Yu CW. Risk factors and early identification markers for post-ischemic stroke anxiety and depression. World J Psychiatry 2026; 16(1): 113104

URL https://www.wjgnet.com/2220-3206/full/v16/i1/113104.htm
DOI https://dx.doi.org/10.5498/wjp.v16.i1.113104
Full Article (PDF) WJP-16-113104-with-cover.pdf
Manuscript File 113104_Auto_Edited_065239.docx
Answering Reviewers 113104-answering-reviewers.pdf
Audio Core Tip 113104-audio.mp3
Biostatistics Review Certificate 113104-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 113104-conflict-of-interest-statement.pdf
Copyright License Agreement 113104-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s) 113104-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document 113104-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 113104-non-native-speakers.pdf
Peer-review Report 113104-peer-reviews.pdf
Scientific Misconduct Check 113104-scientific-misconduct-check.png
Scientific Editor Work List 113104-scientific-editor-work-list.pdf
CrossCheck Report 113104-crosscheck-report.pdf