| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Case Report |
| Article Title |
Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Manish Ramesh Balwani, Amit Pasari, Pranjal Kashiv, Chaitanya Shembekar, Manisha Shembekar, Shubham Dubey, Vijay Jeyachandran, Sunny Malde, Sushrut Gupta, Twinkle Pawar, Priyanka Tolani, Mohit Kurundwadkar, Prasad Gurjar, Kapil Sejpal, Charulata Bawankule and Vivek B Kute |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Manish Ramesh Balwani, DM, MD, Professor, Department of Nephrology, Saraswati Kidney Care Center, 13, New Sneh Nagar, Near Jaiprakash Nagar Metro Station, Jaitala Road, Nagpur 440015, Maharashtra, India. balwani.manish@yahoo.com |
| Key Words |
Complement-mediated thrombotic microangiopathy; CFH exon 17 deletion; CFHR3-CFHR1 duplication; Renal transplantation; High-risk pregnancy; Complement dysregulation; Eculizumab-free management; Atypical hemolytic uremic syndrome; Case report |
| Core Tip |
This case highlights a rare instance of successful term pregnancy in a renal transplant recipient with genetically confirmed complement-mediated thrombotic microangiopathy—homozygous complement factor H exon 17 deletion and complement factor H-related (CFHR3-CFHR1) duplication—managed without complement blockade. Despite the dual risk posed by transplantation and pregnancy, careful preconception counseling, immunosuppressive modification, and vigilant multidisciplinary surveillance ensured stable graft function and favorable maternal-fetal outcomes. This report emphasizes individualized, genotype-informed management and adds valuable evidence to guide pregnancy counseling in women with complement dysregulation post-transplant. |
| Publish Date |
2026-01-14 08:39 |
| Citation |
Balwani MR, Pasari A, Kashiv P, Shembekar C, Shembekar M, Dubey S, Jeyachandran V, Malde S, Gupta S, Pawar T, Tolani P, Kurundwadkar M, Gurjar P, Sejpal K, Bawankule C, Kute VB. Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report. World J Transplant 2026; 16(1): 113117 |
| URL |
https://www.wjgnet.com/2220-3230/full/v16/i1/113117.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v16.i1.113117 |
