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Articles Published Processes
11/21/2025 3:54:19 AM | Browse: 72 | Download: 200
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Received |
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2025-08-18 01:14 |
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Peer-Review Started |
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2025-08-18 01:14 |
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First Decision by Editorial Office Director |
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2025-08-26 09:48 |
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Return for Revision |
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2025-08-26 09:48 |
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Revised |
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2025-08-29 03:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-20 02:57 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-20 05:51 |
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Articles in Press |
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2025-10-20 05:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-14 01:55 |
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Publish the Manuscript Online |
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2025-11-21 03:54 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sumanta Das and Sunita Ahlawat |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sumanta Das, Assistant Professor, MD, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Sector 44, Opposite Millenium City Center Metro Station, Gurugram 122002, Haryana, India. sumantad755@gmail.com |
| Key Words |
Dermatofibrosarcoma protuberans; COL1A1::PDGFB; EMILIN; TNC; Molecular diagnostics |
| Core Tip |
Apart from canonical COL1A1::PDGFB fusion, dermtofibrosarcoma harbors an expanding spectrum of gene fusions, which include COL1A2::PDGFB, COL6A3::PDGFD, EMILIN2::PDGFD, TNC::PDGFD, FBN1::CSAD, MAP3K7CL::ERG, SLC2A5::BTBD7, and LARGE1::PRKCA, which influence tumor biology, therapeutic response to treatment, and disease prognosis. Since molecular techniques like fluorescence in situ hybridization and polymerase chain reaction can miss these variants, a comprehensive genomic profiling, like next-generation sequencing or ribonucleic acid sequencing, is necessary for correct diagnosis, risk stratification, and eligibility for personalized medicine, particularly in morphologically challenging fibrosarcomatous variants. |
| Publish Date |
2025-11-21 03:54 |
| Citation |
Das S, Ahlawat S. Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans. World J Clin Cases 2025; 13(33): 113167
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| URL |
https://www.wjgnet.com/2307-8960/full/v13/i33/113167.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i33.113167 |
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