Publication Name	World Journal of Clinical Cases
Manuscript ID	113167
Country	India

Received	2025-08-18 01:14
Peer-Review Started	2025-08-18 01:14
To Make the First Decision
Return for Revision	2025-08-26 09:48
Revised	2025-08-29 03:50
Second Decision	2025-10-20 02:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-10-20 05:51
Articles in Press	2025-10-20 05:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-11-14 01:55
Publish the Manuscript Online	2025-11-21 03:54

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans
Manuscript Source	Invited Manuscript
All Author List	Sumanta Das and Sunita Ahlawat
ORCID	Author(s) ORCID Number Sumanta Das http://orcid.org/0000-0003-3592-9533 Sunita Ahlawat http://orcid.org/0000-0002-0775-4011
Funding Agency and Grant Number
Corresponding Author	Sumanta Das, Assistant Professor, MD, Department of Pathology, Agilus Diagnostics Ltd, Fortis Memorial Research Institute, Sector 44, Opposite Millenium City Center Metro Station, Gurugram 122002, Haryana, India. sumantad755@gmail.com
Key Words	Dermatofibrosarcoma protuberans; COL1A1::PDGFB; EMILIN; TNC; Molecular diagnostics
Core Tip	Apart from canonical COL1A1::PDGFB fusion, dermtofibrosarcoma harbors an expanding spectrum of gene fusions, which include COL1A2::PDGFB, COL6A3::PDGFD, EMILIN2::PDGFD, TNC::PDGFD, FBN1::CSAD, MAP3K7CL::ERG, SLC2A5::BTBD7, and LARGE1::PRKCA, which influence tumor biology, therapeutic response to treatment, and disease prognosis. Since molecular techniques like fluorescence in situ hybridization and polymerase chain reaction can miss these variants, a comprehensive genomic profiling, like next-generation sequencing or ribonucleic acid sequencing, is necessary for correct diagnosis, risk stratification, and eligibility for personalized medicine, particularly in morphologically challenging fibrosarcomatous variants.
Publish Date	2025-11-21 03:54
Citation	<p>Das S, Ahlawat S. Beyond COL1A1::PDGFB: Rare fusions and their clinical implications in dermatofibrosarcoma protuberans. <i>World J Clin Cases</i> 2025; 13(33): 113167</p>
URL	https://www.wjgnet.com/2307-8960/full/v13/i33/113167.htm
DOI	https://dx.doi.org/10.12998/wjcc.v13.i33.113167

Full Article (PDF)	WJCC-13-113167-with-cover.pdf
Manuscript File	113167_Auto_Edited_034625.docx
Answering Reviewers	113167-answering-reviewers.pdf
Audio Core Tip	113167-audio.mp3
Conflict-of-Interest Disclosure Form	113167-conflict-of-interest-statement.pdf
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Non-Native Speakers of English Editing Certificate	113167-non-native-speakers.pdf
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Scientific Editor Work List	113167-scientific-editor-work-list.pdf
CrossCheck Report	113167-crosscheck-report.pdf