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Publication Name World Journal of Gastroenterology
Manuscript ID 113187
Country China
Received
2025-08-19 02:15
Peer-Review Started
2025-08-19 02:16
First Decision by Editorial Office Director
2025-08-27 09:50
Return for Revision
2025-08-27 09:50
Revised
2025-09-10 07:03
Publication Fee Transferred
2025-09-11 03:46
Second Decision by Editor
2025-11-26 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-11-26 06:42
Articles in Press
2025-11-26 06:42
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-12 03:16
Publish the Manuscript Online
2026-01-16 11:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Stemness CD24 activation promotes hepatocellular carcinoma progression via an immune escape mechanism
Manuscript Source Unsolicited Manuscript
All Author List Yin Cai, Lu-Yin Liu, Xiao-Xiao Xia, Hao Tang, Min Xu, Wen-Li Sai, Deng-Fu Yao and Min Yao
ORCID
Author(s) ORCID Number
Yin Cai http://orcid.org/0000-0003-4616-2032
Lu-Yin Liu http://orcid.org/0009-0004-2294-2362
Xiao-Xiao Xia http://orcid.org/0009-0009-8983-0361
Hao Tang http://orcid.org/0009-0007-9696-6836
Min Xu http://orcid.org/0009-0006-5139-9914
Wen-Li Sai http://orcid.org/0000-0002-9618-2720
Deng-Fu Yao http://orcid.org/0000-0002-3448-7756
Min Yao http://orcid.org/0000-0002-5473-0186
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 32470985
Nantong S & T Programs of China MS2024051
Federation for Prevention & Control of Infectious Diseases of China NTCRB2025016
Corresponding Author Min Yao, PhD, Postdoc, Professor, Department of Immunology, Medical School of Nantong University, Nantong University, No. 19 Qixiu Road, Nantong 226001, Jiangsu Province, China. erbei@ntu.edu.cn
Key Words Clusters of differentiation 24; Hepatocarcinogenesis; Programmed death-ligand 1; Biomarker; Chronic liver disease
Core Tip Upregulated clusters of differentiation 24 (CD24) expression is associated with hepatocellular carcinoma progression. CD24, a marker of liver cancer stem cells, might exert its oncogenic regulatory effects on the malignancy of chronic liver diseases through the activation of programmed death-ligand 1 signaling. Clinical investigations and hepatocarcinogenesis models have confirmed that upregulated CD24 promotes hepatocyte malignancy via immune escape mechanisms and could be a favorable biomarker for monitoring hepatocarcinogenesis.
Publish Date 2026-01-16 11:31
Citation

Cai Y, Liu LY, Xia XX, Tang H, Xu M, Sai WL, Yao DF, Yao M. Stemness CD24 activation promotes hepatocellular carcinoma progression via an immune escape mechanism. World J Gastroenterol 2026; 32(3): 113187

URL https://www.wjgnet.com/1007-9327/full/v32/i3/113187.htm
DOI https://dx.doi.org/10.3748/wjg.v32.i3.113187
Full Article (PDF) WJG-32-113187-with-cover.pdf
The ARRIVE Guidelines 113187-The-ARRIVE-Guidelines.pdf
Manuscript File 113187_Auto_Edited_063536.docx
Answering Reviewers 113187-answering-reviewers.pdf
Audio Core Tip 113187-audio.mp3
Biostatistics Review Certificate 113187-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 113187-conflict-of-interest-statement.pdf
Copyright License Agreement 113187-copyright-assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 113187-institutional-animal-care-and-use-committee-statement.pdf
Institutional Review Board Approval Form or Document 113187-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate 113187-non-native-speakers.pdf
Peer-review Report 113187-peer-reviews.pdf
Scientific Misconduct Check 113187-scientific-misconduct-check.png
Scientific Editor Work List 113187-scientific-editor-work-list.pdf
CrossCheck Report 113187-crosscheck-report.pdf