| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Pancreatic neuroendocrine microtumors in the elderly: A retrospective study using cadaveric pancreatic tissue
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Yang, Ke Ren, Xiang-Quan Chen, Taku Toriumi, Yutaro Natsuyama, Jun Li, Aoi Sukeda, Toshitaka Nagao and Shuang-Qin Yi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan |
25K10147 |
|
| Corresponding Author |
Shuang-Qin Yi, MD, PhD, Professor, Department of Frontier Health Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, 7-2-10, Higashiogu, Arakawa-Ku, Tokyo 116-8551, Japan. yittmniu@tmu.ac.jp |
| Key Words |
Pancreatic neuroendocrine microtumors; Elderly populations; Cadaveric study; Well-differentiated pancreatic neuroendocrine neoplasms; Non-functioning tumor; Chromogranin A; Synaptophysin |
| Core Tip |
This cadaveric study identified pancreatic neuroendocrine microtumors (PNEMTs) in 5.9% of predominantly elderly individuals (mean age: 88.0 ± 9.3 years) that were small (≤ 2.2 mm), secreted glucagon, had minimal proliferative activity (Ki-67 near negative), and had well-differentiated grade 1 lesions. These findings emphasize that biologically indolent PNEMTs are significantly more prevalent in the aged population than are clinically recognized. Given that tumor enlargement may be associated with malignant potential, early detection is of critical clinical importance for managing incidental lesions. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Yang T, Ren K, Chen XQ, Toriumi T, Natsuyama Y, Li J, Sukeda A, Nagao T, Yi SQ. Pancreatic neuroendocrine microtumors in the elderly: A retrospective study using cadaveric pancreatic tissue. World J Gastrointest Oncol 2025; 17(12): 113198 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113198.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113198 |
