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Articles Published Processes
12/19/2025 10:39:43 AM | Browse: 72 | Download: 381
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Received |
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2025-08-19 02:24 |
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Peer-Review Started |
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2025-08-19 02:24 |
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First Decision by Editorial Office Director |
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2025-09-03 07:31 |
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Return for Revision |
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2025-09-03 07:31 |
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Revised |
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2025-09-29 14:12 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-07 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-07 08:36 |
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Articles in Press |
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2025-11-07 08:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-10 05:05 |
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Publish the Manuscript Online |
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2025-12-19 10:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosis via Bax/Bcl-2/caspase-3 signaling pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hai-Feng Chen, Chen Gong, Ting-Ting Wang, Jian-Xin Zhu and Wei-Ping Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Taicang Science and Technology Program |
TC2021JCYL21 |
| “National Tutor System” Training Program for Health Youth Key Talents in Suzhou |
Qngg2023042 |
| Suzhou Science and Technology Bureau |
SYW2024152 |
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| Corresponding Author |
Wei-Ping Li, Department of Gastrointestinal Surgery, Taicang Affiliated Hospital of Soochow University (The First People’s Hospital of Taicang), No. 58 South Changsheng Road, Suzhou 215400, Jiangsu Province, China. question12397@163.com |
| Key Words |
Tumor necrosis factor-α; Abnormal glucose metabolism; Acute pancreatitis; Apoptosis; Bax; Bcl-2; Caspase-3 |
| Core Tip |
Acute pancreatitis (AP) often leads to abnormal glucose metabolism (AGM). This study investigated the role of tumor necrosis factor-α (TNF-α) in AP-associated AGM, and our results showed elevated TNF-α promoted β-cell apoptosis via the Bax/Bcl-2/caspase-3 signaling pathway, contributing to AGM. Inhibiting TNF-α reduced apoptosis and improved AGM, indicating its potential as a therapeutic target for preventing AGM after AP. |
| Publish Date |
2025-12-19 10:39 |
| Citation |
Chen HF, Gong C, Wang TT, Zhu JX, Li WP. Tumor necrosis factor-α promotes abnormal glucose metabolism after acute pancreatitis by inducing islet β-cell apoptosis via Bax/Bcl-2/caspase-3 signaling pathway. World J Gastroenterol 2025; 31(47): 113205 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i47/113205.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i47.113205 |
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