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Articles Published Processes
2/6/2026 8:43:33 AM | Browse: 67 | Download: 189
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Received |
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2025-08-20 02:44 |
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Peer-Review Started |
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2025-08-27 00:34 |
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First Decision by Editorial Office Director |
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2025-10-10 03:51 |
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Return for Revision |
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2025-10-10 03:51 |
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Revised |
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2025-10-24 13:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-12 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-12 07:39 |
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Articles in Press |
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2025-12-12 07:39 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-26 06:59 |
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Publish the Manuscript Online |
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2026-02-06 08:43 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Editorial |
| Article Title |
Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Javier Donate-Correa and Carlos E Martínez-Alberto |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Javier Donate-Correa, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario S/N, Santa Cruz de Tenerife 38010, Spain. jdonatecorrea@gmail.com |
| Key Words |
Diabetic cardiomyopathy; Endothelial dysfunction; Ferroptosis; MicroRNA-29b-3p; Sirtuin 1; Farrerol |
| Core Tip |
Diabetic cardiomyopathy (DCM) is a diabetes-related form of heart failure that lacks targeted therapies. Recent evidence identifies endothelial ferroptosis, an iron-dependent form of cell death, as a central driver of cardiac microvascular injury in DCM. Guo et al. demonstrate that Farrerol, a natural flavonoid, inhibits ferroptosis by downregulating microRNA-29b-3p and restoring sirtuin 1 signaling in endothelial cells, thereby improving cardiac function and reducing fibrosis in diabetic mice. Targeting endothelial ferroptosis through the microRNA-29b-3p/sirtuin 1 pathway represents a novel disease-modifying strategy for DCM. |
| Publish Date |
2026-02-06 08:43 |
| Citation |
Donate-Correa J, Martínez-Alberto CE. Farrerol and the miR-29b-3p/sirtuin 1 pathway: A mechanistic breakthrough in protecting the diabetic heart. World J Diabetes 2026; 17(2): 113221 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i2/113221.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i2.113221 |
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