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Articles Published Processes
3/12/2026 9:18:19 AM | Browse: 5 | Download: 14
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Received |
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2025-08-25 00:57 |
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Peer-Review Started |
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2025-08-27 00:38 |
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First Decision by Editorial Office Director |
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2025-10-24 06:36 |
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Return for Revision |
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2025-10-24 06:36 |
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Revised |
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2025-11-12 15:20 |
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Publication Fee Transferred |
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2025-11-23 13:52 |
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Second Decision by Editor |
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2026-01-23 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-23 08:02 |
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Articles in Press |
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2026-01-23 08:02 |
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Edit the Manuscript by Language Editor |
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2026-01-29 03:15 |
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Typeset the Manuscript |
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2026-03-09 06:27 |
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Publish the Manuscript Online |
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2026-03-12 09:18 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Amomum villosum extract alleviates diabetic neuropathy via PI3K/AKT-mediated antioxidative and anti-apoptotic effects
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Quan Kou, Ming-Jie Liu, Xiao-Lan Gao and Fu-Rong Guo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dong-Quan Kou, School of Pharmaceutical Sciences and Yunnan Provincial Key Laboratory of Pharmacology for Natural Medicines, Kunming Medical University, No. 191, Renmin West Road, Xishan District, Kunming 650500, Yunnan Province, China. rmkdquan@163.com |
| Key Words |
Amomum villosum Lour.; Diabetic peripheral neuropathy; PI3K/AKT; Oxidative stress; Apoptosis |
| Core Tip |
Diabetic peripheral neuropathy (DPN) lacks effective therapies beyond symptomatic relief. This study demonstrates that the aqueous extract of Amomum villosum Lour. (AVL) significantly alleviates DPN in rats by activating the PI3K/AKT signaling pathway. AVL reduced oxidative stress, inflammation, and neuronal apoptosis in dorsal root ganglion tissues, thereby improving pain thresholds. Inhibition of PI3K/AKT abrogated these protective effects. These findings highlight AVL as a promising natural medicine with multi-targeted neuroprotective properties and provide mechanistic evidence for its potential application in DPN treatment. |
| Publish Date |
2026-03-12 09:18 |
| Citation |
Kou DQ, Liu MJ, Gao XL, Guo FR. Amomum villosum extract alleviates diabetic neuropathy via PI3K/AKT-mediated antioxidative and anti-apoptotic effects. World J Diabetes 2026; 17(3): 113249 |
| URL |
https://www.wjgnet.com/1948-9358/full/v17/i3/113249.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v17.i3.113249 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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