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Articles Published Processes
11/14/2025 12:56:14 AM | Browse: 67 | Download: 226
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Received |
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2025-08-21 05:44 |
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Peer-Review Started |
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2025-08-21 05:44 |
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First Decision by Editorial Office Director |
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2025-09-08 10:19 |
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Return for Revision |
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2025-09-08 12:44 |
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Revised |
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2025-09-21 17:23 |
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Publication Fee Transferred |
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2025-09-22 11:36 |
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Second Decision by Editor |
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2025-10-09 01:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-09 03:22 |
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Articles in Press |
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2025-10-09 03:22 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 06:39 |
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Publish the Manuscript Online |
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2025-11-14 00:56 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Report |
| Article Title |
FGFR2 fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Yun Hong, Chun-Hui Shou, Wei-Li Yang, Xiao-Dong Wang, Qing Zhang, Xiao-Sun Liu and Ji-Ren Yu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ji-Ren Yu, PhD, Professor, Department of Gastrointestinal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. yujr0909@zju.edu.cn |
| Key Words |
Gastrointestinal stromal tumor; FGFR2 rearrangement; Next-generation sequencing; Imatinib; Case report |
| Core Tip |
Herein, we report, for the first time, novel FGFR2 rearrangements FGFR2-CIT/intergenic-FGFR2 and FGFR2-CAMK2G/FGFR2-VCL fusions as potential primary oncogenic drivers in two patients with KIT/PDGFRA wild-type gastrointestinal stromal tumors (GISTs). Both patients achieved sustained remission following adjuvant imatinib, challenging the notion that non-canonical alterations preclude tyrosine kinase inhibitor response. These findings might expand the molecular spectrum of GISTs and suggest that FGFR2 fusions might define a distinct subtype with potential sensitivity to FGFR-targeted therapies, offering new avenues for precision treatment in imatinib-resistant or advanced disease cases. |
| Publish Date |
2025-11-14 00:56 |
| Citation |
Hong YY, Shou CH, Yang WL, Wang XD, Zhang Q, Liu XS, Yu JR. FGFR2 fusions as novel oncogenic drivers in gastrointestinal stromal tumors: Two case reports and review of literature. World J Gastrointest Oncol 2025; 17(11): 113262 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i11/113262.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i11.113262 |
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