| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Hematology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdul Rehman, Mehsim Abid, Hira Jamil, Sadia Siddique, Sagar Parkash, FNU Nasrullah, FNU Sapna, Bhawna Lohana, Kiran Lohana, Inshal Jawed, Mohammad Tufail and Mohammad Sarim Sharaf |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Inshal Jawed, Chief Physician, Senior Researcher, Department of Medicine, Dow University of Health Sciences, Baba-e-urdu Karachi, Karachi 75350, Sindh, Pakistan. inshaljwd@gmail.com |
| Key Words |
Heparin-induced thrombocytopenia; Fondaparinux; Argatroban; Bivalirudin; Anticoagulation; Systematic review |
| Core Tip |
Heparin-induced thrombocytopenia is life-threatening and needs alternative anticoagulation. The systematic review included sixteen studies on 2867 patients treated with fondaparinux, bivalirudin and argatroban. None of these agents proved superior, and evidence certainty was low to very low, mainly because most studies were observational and showed heterogeneity. All three agents demonstrated acceptable efficacy and safety; however, treatment choice should be patient specific and clinically informed. Randomized trials are urgently needed to support evidence-based treatment decisions. |
| Publish Date |
2026-04-23 11:05 |
| Citation |
Rehman A, Abid M, Jamil H, Siddique S, Parkash S, Nasrullah F, Sapna F, Lohana B, Lohana K, Jawed I, Tufail M, Sharaf MS. Comparative effectiveness of parenteral anticoagulants (fondaparinux, argatroban, bivalirudin) in heparin-induced thrombocytopenia: A systematic review. World J Methodol 2026; 16(2): 113265 |
| URL |
https://www.wjgnet.com/2222-0682/full/v16/i2/113265.htm |
| DOI |
https://dx.doi.org/10.5662/wjm.v16.i2.113265 |
