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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 113266
Country China
Received
2025-08-20 04:05
Peer-Review Started
2025-08-20 04:05
First Decision by Editorial Office Director
2025-10-10 03:13
Return for Revision
2025-10-10 03:13
Revised
2025-11-23 08:34
Publication Fee Transferred
2025-11-26 10:01
Second Decision by Editor
2026-01-13 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-01-14 06:41
Articles in Press
2026-01-14 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-29 09:09
Publish the Manuscript Online
2026-04-08 07:28
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Systematic Reviews
Article Title Cost-effectiveness analysis of seven treatments vs sorafenib as first-line therapy for advanced hepatocellular carcinoma in China
Manuscript Source Unsolicited Manuscript
All Author List Zhi-Huan Lin, Yan He, Hai-Xia Xu and Liang Xiao
ORCID
Author(s) ORCID Number
Hai-Xia Xu http://orcid.org/0009-0000-1720-6521
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Shen Zhen City No. JCYJ20220530151002004
Corresponding Author Hai-Xia Xu, MD, Department of Medical Oncology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, No. 3002 Sungang West Road, Futian District, Shenzhen 518035, Guangdong Province, China. xhx198345@vip.163.com
Key Words Hepatocellular carcinoma; Cost-effectiveness; Network meta-analysis; First-line treatment; China
Core Tip The economic evaluation of various first-line treatment regimens for advanced hepatocellular carcinoma is crucial, yet such analyses remain scarce. This study conducted a network meta-analysis of 23 first-line regimens for advanced hepatocellular carcinoma and subsequently performed a cost-effectiveness analysis on seven highly efficacious regimens from the perspective of the Chinese healthcare system. The results indicated that lenvatinib combined with transarterial chemoembolization emerged as the most favorable first-line treatment under current economic conditions in China, achieving a 67.9% probability of being the most cost-effective option. This study contributes a novel perspective to inform clinical decision-making for healthcare professionals.
Publish Date 2026-04-08 07:28
Citation

Lin ZH, He Y, Xu HX, Xiao L. Cost-effectiveness analysis of seven treatments vs sorafenib as first-line therapy for advanced hepatocellular carcinoma in China. World J Gastrointest Oncol 2026; 18(4): 113266

URL https://www.wjgnet.com/1948-5204/full/v18/i4/113266.htm
DOI https://dx.doi.org/10.4251/wjgo.v18.i4.113266
Full Article (PDF) WJGO-18-113266-with-cover.pdf
PRISMA 2009 Checklist 113266-PRISMA-2009-Checklist.pdf
Manuscript File 113266_Auto_Edited_082428.docx
Answering Reviewers 113266-answering-reviewers.pdf
Audio Core Tip 113266-audio.wav
Biostatistics Review Certificate 113266-biostatistics-statement.pdf
Conflict-of-Interest Disclosure Form 113266-conflict-of-interest-statement.pdf
Copyright License Agreement 113266-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 113266-non-native-speakers.pdf
Supplementary Material 113266-supplementary-material.pdf
Peer-review Report 113266-peer-reviews.pdf
Scientific Misconduct Check 113266-scientific-misconduct-check.png
Scientific Editor Work List 113266-scientific-editor-work-list.pdf
CrossCheck Report 113266-crosscheck-report.pdf