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Articles Published Processes
12/11/2025 8:20:59 AM | Browse: 112 | Download: 332
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Received |
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2025-08-26 09:08 |
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Peer-Review Started |
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2025-08-26 09:08 |
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First Decision by Editorial Office Director |
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2025-09-18 08:47 |
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Return for Revision |
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2025-09-18 08:47 |
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Revised |
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2025-09-26 15:40 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-07 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-07 08:18 |
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Articles in Press |
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2025-11-07 08:18 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-28 14:34 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Bidirectional relationship between depression and the risk and prognosis of gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhe Chen, Ting-Jie Gong and Lu Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lu Zhao, Doctorate Student, Department of Oncology, Wuxi Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, No. 8 Zhongnan West Road, Binhu District, Wuxi 214000, Jiangsu Province, China. lorraine0318@163.com |
| Key Words |
Gastric cancer; Depression; Bidirectional relationship; Psychological factors; Quality of life |
| Core Tip |
This review reveals a bidirectional relationship between depression and gastric cancer. Depression activates the sympathetic nervous system and the hypothalamic–pituitary–adrenal (HPA) axis, promoting tumor progression through pathways such as the β2-adrenergic receptor (β2-AR). Conversely, gastric cancer induces depression through psychosocial and pathophysiological mechanisms. This vicious cycle provides a theoretical basis for clinical interventions designed to improve patient outcomes and quality of life. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Chen Z, Gong TJ, Zhao L. Bidirectional relationship between depression and the risk and prognosis of gastric cancer. World J Gastrointest Oncol 2025; 17(12): 113272 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113272.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113272 |
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