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Articles Published Processes
12/11/2025 8:20:55 AM | Browse: 4 | Download: 1
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Received |
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2025-08-21 06:10 |
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Peer-Review Started |
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2025-08-21 06:10 |
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First Decision by Editorial Office Director |
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2025-09-17 08:50 |
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Return for Revision |
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2025-09-17 09:15 |
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Revised |
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2025-09-30 02:21 |
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Publication Fee Transferred |
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2025-10-01 23:18 |
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Second Decision by Editor |
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2025-10-29 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-29 06:55 |
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Articles in Press |
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2025-10-29 06:55 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 00:32 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zulihumaer Aizimuaji, Nan Hu, Hai-Yang Li, Xi-Jun Wang, Sheng Ma, Ya-Ru Wang, Rui-Qi Zheng, Zhuo Li, Huan Zhao, Wei-Qi Rong and Ting Xiao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
2023YFF0613304 |
| Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences |
2023-I2M-2-004 |
| Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences |
2024-I2M-C&T-B-069 |
| Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences |
2025-I2M-C&T-B-057 |
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| Corresponding Author |
Wei-Qi Rong, Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan South Lane, Beijing 100021, China. dr_rongweiqi@163.com |
| Key Words |
Hepatocellular carcinoma; Hepatitis B virus; Mutation; Polymerase chain reaction; Hepatectomy; Nomograms; Prognosis |
| Core Tip |
Telomerase reverse transcriptase (TERT) promoter mutation is the most frequent genetic alteration in hepatitis B virus-related hepatocellular carcinoma, yet its prognostic role remains uncertain. In this study, optimized digital polymerase chain reaction outperformed Sanger sequencing in detecting TERT promoter mutations. Patients with TERT mutations had significantly worse survival and higher recurrence risk after hepatectomy. Incorporating TERT mutation status into a nomogram model provides a practical tool for individualized prognosis prediction and may guide precision treatment in hepatitis B virus-related hepatocellular carcinoma. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Aizimuaji Z, Hu N, Li HY, Wang XJ, Ma S, Wang YR, Zheng RQ, Li Z, Zhao H, Rong WQ, Xiao T. Optimized digital polymerase chain reaction enables detection of telomerase reverse transcriptase C228T mutation for prognostic assessment in hepatocellular carcinoma. World J Gastrointest Oncol 2025; 17(12): 113289 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113289.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113289 |
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