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Articles Published Processes
2/11/2026 7:19:22 AM | Browse: 124 | Download: 488
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Received |
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2025-08-21 06:16 |
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Peer-Review Started |
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2025-08-21 06:16 |
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First Decision by Editorial Office Director |
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2025-09-09 10:24 |
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Return for Revision |
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2025-09-09 10:24 |
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Revised |
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2025-09-17 08:49 |
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Publication Fee Transferred |
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2025-09-25 04:01 |
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Second Decision by Editor |
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2025-12-23 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-23 06:06 |
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Articles in Press |
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2025-12-23 06:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-05 01:04 |
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Publish the Manuscript Online |
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2026-02-11 07:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Chan Li, Shun-Zi Shao, Yu-Hang Zhang, Yu Zhou, Wen-Tao Shang, Yuan Gao, Qi-Bin He, Qing-Long Guo, Chuan-Yong Guo and Xiao-Bo Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Double First-Class University” Project of China Pharmaceutical University |
No. CPU2022PZQ11 |
| Nanjing Medical Science and Technology Development Foundation |
No. YKK24223 |
| Outstanding Young Teacher of Qinglan Project in Jiangsu Province |
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| Corresponding Author |
Xiao-Bo Zhang, PhD, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing 210009, Jiangsu Province, China. xiaobozhangxibo@126.com |
| Key Words |
Gastric carcinoma; Bortezomib; Wogonin derivative V8; Lysosome; Drug resistance; Transcription factor EB; Patient-derived organoids |
| Core Tip |
We identified lysosomal trapping as a key mechanism of bortezomib resistance (BTZ) in gastric cancer. The novel agent V8 disrupts lysosomes, releasing BTZ to enhance proteasome targeting and induce lethal proteotoxic stress. The V8-BTZ combination shows strong synergy in cells, xenografts, and patient organoids, supporting its clinical potential for overcoming resistance. |
| Publish Date |
2026-02-11 07:19 |
| Citation |
Li SC, Shao SZ, Zhang YH, Zhou Y, Shang WT, Gao Y, He QB, Guo QL, Guo CY, Zhang XB. Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. World J Gastroenterol 2026; 32(8): 113299
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| URL |
https://www.wjgnet.com/1007-9327/full/v32/i8/113299.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i8.113299 |
Copyright © 1993-2026 Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA. All rights reserved, including rights relating to text and data mining, AI training, and similar technologies. For open-access content, the applicable copyright and licensing terms govern.
