| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Si-Chan Li, Shun-Zi Shao, Yu-Hang Zhang, Yu Zhou, Wen-Tao Shang, Yuan Gao, Qi-Bin He, Qing-Long Guo, Chuan-Yong Guo and Xiao-Bo Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| “Double First-Class University” Project of China Pharmaceutical University |
No. CPU2022PZQ11 |
| Nanjing Medical Science and Technology Development Foundation |
No. YKK24223 |
| Outstanding Young Teacher of Qinglan Project in Jiangsu Province |
|
|
| Corresponding Author |
Xiao-Bo Zhang, PhD, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, No. 24 Tongjia Lane, Gulou District, Nanjing 210009, Jiangsu Province, China. xiaobozhangxibo@126.com |
| Key Words |
Gastric carcinoma; Bortezomib; Wogonin derivative V8; Lysosome; Drug resistance; Transcription factor EB; Patient-derived organoids |
| Core Tip |
We identified lysosomal trapping as a key mechanism of bortezomib resistance (BTZ) in gastric cancer. The novel agent V8 disrupts lysosomes, releasing BTZ to enhance proteasome targeting and induce lethal proteotoxic stress. The V8-BTZ combination shows strong synergy in cells, xenografts, and patient organoids, supporting its clinical potential for overcoming resistance. |
| Publish Date |
2026-02-11 07:19 |
| Citation |
Li SC, Shao SZ, Zhang YH, Zhou Y, Shang WT, Gao Y, He QB, Guo QL, Guo CY, Zhang XB. Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. World J Gastroenterol 2026; 32(8): 113299 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i8/113299.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i8.113299 |
