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Articles Published Processes
12/17/2025 6:45:15 AM | Browse: 345 | Download: 742
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Received |
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2025-08-22 09:12 |
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Peer-Review Started |
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2025-08-22 09:12 |
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First Decision by Editorial Office Director |
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2025-09-08 09:54 |
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Return for Revision |
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2025-09-08 09:54 |
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Revised |
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2025-09-18 17:38 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-06 02:43 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-06 07:30 |
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Articles in Press |
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2025-11-06 07:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-09 00:13 |
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Publish the Manuscript Online |
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2025-12-17 06:45 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Adrián Cardín-Pereda, Daniel García-Sánchez, Itziar Álvarez-Iglesias, Jennifer Cabello-Sanz and Flor M Pérez-Campo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Flor M Pérez-Campo, Assistant Professor, PhD, Senior Researcher, Department of Molecular Biology, Instituto de Investigación Sanitaria Marqués de Valdecilla, Faculty of Medicine, University of Cantabria, Avda Cardenal Herrera Oria S/N, Santander 39011, Cantabria, Spain. f.perezcampo@unican.es |
| Key Words |
Idiopathic osteonecrosis of the femoral head; Mesenchymal stem cells; Proliferation; Differentiation; Lineage specification; Adipogenesis; Osteogenesis |
| Core Tip |
Directly harvested bone marrow mesenchymal stem cells from femoral heads of patients with idiopathic osteonecrosis show higher proliferation but reduced osteogenesis, increased adipogenesis and upregulated nuclear factor kappa B target genes relative to osteoarthritis controls. This hyperproliferative yet lineage-skewed phenotype offers a mechanistic link between cellular dysfunction and failed structural repair in osteonecrosis of the femoral head and supports the use of therapies that reprogramme mesenchymal stem cells fate and the bone marrow microenvironment. |
| Publish Date |
2025-12-17 06:45 |
| Citation |
Cardín-Pereda A, García-Sánchez D, Álvarez-Iglesias I, Cabello-Sanz J, Pérez-Campo FM. Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head. World J Orthop 2025; 16(12): 113320
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| URL |
https://www.wjgnet.com/2218-5836/full/v16/i12/113320.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v16.i12.113320 |
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