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Articles Published Processes
1/15/2026 8:12:51 AM | Browse: 1 | Download: 1
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Received |
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2025-08-22 08:27 |
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Peer-Review Started |
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2025-08-22 08:27 |
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First Decision by Editorial Office Director |
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2025-09-08 09:27 |
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Return for Revision |
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2025-09-08 09:27 |
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Revised |
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2025-09-16 11:08 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-24 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-25 08:07 |
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Articles in Press |
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2025-11-25 08:07 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-30 09:32 |
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Publish the Manuscript Online |
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2026-01-15 08:12 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Deciphering Teochew population’s genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ru-Tong Wang, Ying-Qi Feng, Si-Qi Tu and Shen Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shen Yang, Academic Fellow, Chief, PhD, PsyD, Department of Neurology, the First People’s Hospital of Xiangtan City, No. 100, Shuyuan Road, Yuetang District, Xiangtan 411100, Hunan Province, China. doctoryangshen@163.com |
| Key Words |
Apolipoprotein E; Lipoprotein(a) kringle IV type 2; Teochew population; Synergistic effect; Risk stratification |
| Core Tip |
This study identifies a novel synergistic cardiometabolic protective pathway in the genetically distinct Teochew (Chaozhou) Han population of southern China. We demonstrate that the co-presence of the apolipoprotein E (APOE) ε2 allele and high copy number variation of the lipoprotein(a) kringle IV type 2gene significantly reduces coronary heart disease risk, contrasting with previous reports on APOE ε2 in Asians. This unique gene-environment interaction, potentially modulated by the local seafood-rich diet, offers a population-specific biomarker for optimized coronary heart disease risk stratification. Clinical translation emphasizes integrating APOE/lipoprotein(a) kringle IV type 2 copy number variation screening with solute carrier organic anion transporter family member 1B1 pharmacogenetics to guide precision statin therapy and personalized prevention strategies. |
| Publish Date |
2026-01-15 08:12 |
| Citation |
Wang RT, Feng YQ, Tu SQ, Yang S. Deciphering Teochew population’s genetic protective barrier: Apolipoprotein E- lipoprotein(a) kringle IV type 2 synergy as novel cardioprotective pathway. World J Cardiol 2026; 18(1): 113327 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i1/113327.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i1.113327 |
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