Publication Name	World Journal of Transplantation
Manuscript ID	11334
Country	Italy

Received	2014-05-16 08:35
Peer-Review Started	2014-05-18 22:55
To Make the First Decision	2014-06-06 11:02
Return for Revision	2014-06-16 10:57
Revised	2014-06-28 17:41
Second Decision	2014-09-10 13:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-09-10 13:59
Articles in Press	2014-09-10 13:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-10-22 17:08
Publish the Manuscript Online	2014-10-24 17:01

ISSN	2220-3230 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	Complement cascade and kidney transplantation: The rediscovery of an ancient enemy
Manuscript Source	Invited Manuscript
All Author List	Alberto Mella, Maria Messina, Antonio Lavacca and Luigi Biancone
Funding Agency and Grant Number
Corresponding Author	Luigi Biancone, MD, PhD, Renal Transplantation Unit “A. Vercellone”, Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital and University of Torino, Corso Bramante, 88-10126 Turin, Italy. luigi.biancone@unito.it
Key Words	Complement; Eculizumab; Kidney transplantation
Core Tip	Complement cascade is involved in different types of renal disease, from glomerulonephritides to pre-eclampsia, and the availability of new drugs, able to inhibit different steps of the cascade, re-defined this ancient pathway, and its blockage both in native and transplanted kidneys, as a new challenging frontier in renal disease treatment. In this review we evaluate the importance of complement cascade in renal transplantation diseases, focusing on available treatments, and we propose a speculative identification of areas where complement inhibition may be a promising strategy.
Publish Date	2014-10-24 17:01
Citation	Mella A, Messina M, Lavacca A, Biancone L. Complement cascade and kidney transplantation: The rediscovery of an ancient enemy. World J Transplant 2014; 4(3): 168-175
URL	http://www.wjgnet.com/2220-3230/full/v4/i3/168.htm
DOI	http://dx.doi.org/10.5500/wjt.v4.i3.168

Full Article (PDF)	WJT-4-168.pdf
Full Article (Word)	WJT-4-168.doc
Manuscript File	11334-Review.doc
Answering Reviewers	11334-Answering reviewers.pdf
Copyright License Agreement	11334-Copyright assignment.pdf
Peer-review Report	11334-Peer review(s).pdf
Scientific Misconduct Check	11334-CrossCheck.jpg
Scientific Editor Work List	11334-Scientific editor work list.pdf