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Articles Published Processes
10/24/2014 5:02:00 PM | Browse: 1182 | Download: 1282
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Received |
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2014-05-16 08:35 |
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Peer-Review Started |
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2014-05-18 22:55 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-06-16 10:57 |
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Revised |
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2014-06-28 17:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-09-10 13:37 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-09-10 13:59 |
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Articles in Press |
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2014-09-10 13:59 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2014-10-22 17:08 |
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Publish the Manuscript Online |
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2014-10-24 17:01 |
| Category |
Transplantation |
| Manuscript Type |
Review |
| Article Title |
Complement cascade and kidney transplantation: The rediscovery of an ancient enemy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alberto Mella, Maria Messina, Antonio Lavacca and Luigi Biancone |
| Funding Agency and Grant Number |
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| Corresponding Author |
Luigi Biancone, MD, PhD, Renal Transplantation Unit “A. Vercellone”, Division of Nephrology Dialysis and Transplantation, Department of Medical Sciences, Città della Salute e della Scienza Hospital and University of Torino, Corso Bramante, 88-10126 Turin, Italy. luigi.biancone@unito.it
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| Key Words |
Complement; Eculizumab; Kidney transplantation |
| Core Tip |
Complement cascade is involved in different types of renal disease, from glomerulonephritides to pre-eclampsia, and the availability of new drugs, able to inhibit different steps of the cascade, re-defined this ancient pathway, and its blockage both in native and transplanted kidneys, as a new challenging frontier in renal disease treatment. In this review we evaluate the importance of complement cascade in renal transplantation diseases, focusing on available treatments, and we propose a speculative identification of areas where complement inhibition may be a promising strategy.
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| Publish Date |
2014-10-24 17:01 |
| Citation |
Mella A, Messina M, Lavacca A, Biancone L. Complement cascade and kidney transplantation: The rediscovery of an ancient enemy. World J Transplant 2014; 4(3): 168-175 |
| URL |
http://www.wjgnet.com/2220-3230/full/v4/i3/168.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v4.i3.168 |
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