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Articles Published Processes
2/12/2026 11:20:21 AM | Browse: 70 | Download: 342
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Received |
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2025-08-25 06:12 |
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Peer-Review Started |
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2025-08-25 06:12 |
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First Decision by Editorial Office Director |
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2025-09-23 09:52 |
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Return for Revision |
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2025-09-26 07:50 |
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Revised |
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2025-10-23 09:05 |
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Publication Fee Transferred |
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2025-10-28 07:01 |
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Second Decision by Editor |
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2025-12-23 02:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-23 09:05 |
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Articles in Press |
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2025-12-23 09:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 02:38 |
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Publish the Manuscript Online |
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2026-02-12 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Predictive tool for evident histological liver injury in chronic hepatitis B patients: Development and validation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhong-Shang Dai, Xin Cao, Yong-Fang Jiang and Bo He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R&D Program of China |
2019YFE0190800 |
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| Corresponding Author |
Bo He, Department of Infectious Diseases, The Second Xiangya Hospital, Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan Province, China. hebo2017@csu.edu.cn |
| Key Words |
Chronic hepatitis B; Evident histological liver injury; Predictive model; Performance; Clinical applicability |
| Core Tip |
This study developed and validated a novel nomogram incorporating L59, platelet count, alanine aminotransferase, and aspartate aminotransferase to predict evident histological liver injury (Ishak ≥ 3 or histologic activity index ≥ 9) in chronic hepatitis B patients. The model demonstrated high accuracy (area under the curve 0.921-0.959) and clinical utility, supported by transcriptomic insights implicating COL1A2 and TGF-β/Smad pathways. This tool enables noninvasive risk stratification, optimizing resource allocation and guiding early intervention. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Dai ZS, Cao X, Jiang YF, He B. Predictive tool for evident histological liver injury in chronic hepatitis B patients: Development and validation. World J Hepatol 2026; 18(2): 113348 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/113348.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.113348 |
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