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Articles Published Processes
2/9/2026 7:34:05 AM | Browse: 1 | Download: 11
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Received |
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2025-08-25 05:25 |
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Peer-Review Started |
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2025-08-25 05:25 |
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First Decision by Editorial Office Director |
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2025-09-18 09:26 |
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Return for Revision |
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2025-09-18 09:26 |
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Revised |
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2025-09-28 08:03 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-28 03:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-28 06:51 |
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Articles in Press |
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2025-11-28 06:51 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-02 07:53 |
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Publish the Manuscript Online |
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2026-02-09 07:34 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Zeng, Qiong Li, Lin Li, Cheng-Fang Xiang and Yi-Jun Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| 2025 Hunan Provincial Natural Science Foundation Regional Joint Fund |
No. 2025JJ70596 |
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| Corresponding Author |
Yi-Jun Wang, Research Fellow, Department of Emergency, The First People’s Hospital of Chenzhou, No. 108 Luo Jia Jin Street, Chenzhou 423000, Hunan Province, China. wangyijun202507@163.com |
| Key Words |
Sepsis; Myocardial injury; Echocardiography; Melatonin; Sirtuin 1; Nuclear factor erythroid 2-related factor 2; Glutathione peroxidase 4 |
| Core Tip |
Sepsis often results in myocardial injury, a major cause of death in affected patients. In this study, we demonstrated that melatonin, an endogenous hormone with antioxidant and anti-inflammatory properties, protects against sepsis-induced myocardial injury. Using both a mouse model and HL-1 cardiomyocytes, we found that melatonin improved cardiac function, reduced oxidative stress, and inhibited ferroptosis by activating the Sirt1/Nrf2/GPX4 pathway. These findings provide novel mechanistic insights and highlight the therapeutic potential of melatonin for septic myocardial injury. |
| Publish Date |
2026-02-09 07:34 |
| Citation |
Zeng M, Li Q, Li L, Xiang CF, Wang YJ. Melatonin regulates Sirt1/Nrf2/GPX4 pathway to inhibit ferroptosis and alleviate myocardial injury caused by sepsis. World J Cardiol 2026; 18(2): 113358 |
| URL |
https://www.wjgnet.com/1949-8462/full/v18/i2/113358.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v18.i2.113358 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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