| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Transcriptome profiles of peripheral blood mononuclear cells differentiate male adolescents with non-alcoholic fatty liver disease from healthy peers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natalia Zeber-Lubecka, Jacek Michalkiewicz, Michalina Dabrowska, Krzysztof Goryca, Aldona Wierzbicka-Rucińska, Wojciech Jańczyk, Irena Jankowska, Anna Świąder-Leśniak, Izabela Kubiszewska, Joanna Ziemska-Legięcka, Piotr Socha and Jerzy Ostrowski |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Centre |
UMO-2018/31/B/NZ5/02735 |
|
| Corresponding Author |
Jerzy Ostrowski, Head, MD, PhD, Professor, Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, fccccc bbbbn, Warsaw 02-781, Mazowieckie, Poland. jostrow@warman.com.pl |
| Key Words |
Fecal extracts; Peripheral blood mononuclear cells; Non-alcoholic fatty liver disease; Differentially expressed genes; Adolescents; Next generation sequencing |
| Core Tip |
We studied immune cells from teenage boys with non-alcoholic fatty liver disease and found that their gene activity and immune responses differ from those of healthy peers. These immune-related changes may serve as early indicators of non-alcoholic fatty liver disease and provide insight into its pathogenesis. Our findings highlight the importance of immune profiling in adolescents and may contribute to future strategies for early diagnosis and intervention. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Zeber-Lubecka N, Michalkiewicz J, Dabrowska M, Goryca K, Wierzbicka-Rucińska A, Jańczyk W, Jankowska I, Świąder-Leśniak A, Kubiszewska I, Ziemska-Legięcka J, Socha P, Ostrowski J. Transcriptome profiles of peripheral blood mononuclear cells differentiate male adolescents with non-alcoholic fatty liver disease from healthy peers. World J Hepatol 2025; 17(12): 113359 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/113359.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.113359 |
