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Articles Published Processes
2/6/2026 6:30:41 AM | Browse: 0 | Download: 0
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Received |
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2025-08-28 02:09 |
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Peer-Review Started |
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2025-08-28 02:09 |
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First Decision by Editorial Office Director |
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2025-09-09 09:56 |
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Return for Revision |
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2025-09-09 09:56 |
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Revised |
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2025-10-14 17:25 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2026-01-04 02:36 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2026-01-04 08:01 |
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Articles in Press |
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2026-01-04 08:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-26 10:30 |
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Publish the Manuscript Online |
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2026-02-06 06:30 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Vivian Zweig, Sanjay Goel and Radhashree Maitra |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Radhashree Maitra, Full Professor, Department of Biology, Yeshiva University, 500 W 185th Street, New York, NY 10033, United States. radhashree.maitra@yu.edu |
| Key Words |
Metastatic colorectal cancer; Oncolytic reovirus; KRAS; Cytokine signaling; Janus kinase/signal transducer and activator of transcription; Phosphoinositide 3-kinase-alpha serine/threonine-protein kinase |
| Core Tip |
This study highlights the prospective of reovirus as both an immunomodulatory agent and a cytotoxic adjuvant to chemotherapy in patients with KRAS-mutant metastatic colorectal cancer. Reovirus induces anti-tumor immunity by modulating cytokine expression - reducing interleukin-8 and vascular endothelial growth factor to inhibit angiogenesis, while elevating interleukin-6, interferon-gamma and regulated upon activation, normal T-cell expressed and secreted to stimulate inflammation. These findings support further investigation into reovirus’s role in reshaping the immune landscape and enhancing therapeutic outcomes in metastatic colorectal cancer. |
| Publish Date |
2026-02-06 06:30 |
| Citation |
Zweig V, Goel S, Maitra R. Gene and cytokine expression profiles of metastatic colorectal cancer patients post reovirus administration. World J Clin Oncol 2026; 17(2): 113428 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i2/113428.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i2.113428 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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