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2/4/2026 7:43:03 AM | Browse: 1 | Download: 0
Publication Name World Journal of Gastrointestinal Endoscopy
Manuscript ID 113439
Country China
Received
2025-08-26 01:18
Peer-Review Started
2025-08-26 01:18
First Decision by Editorial Office Director
2025-09-20 02:26
Return for Revision
2025-09-21 13:41
Revised
2025-10-22 12:13
Publication Fee Transferred
2025-10-23 06:06
Second Decision by Editor
2025-12-05 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-12-05 08:52
Articles in Press
2025-12-05 08:52
Edit the Manuscript by Language Editor
Typeset the Manuscript
2026-01-29 08:11
Publish the Manuscript Online
2026-02-04 07:43
ISSN 1948-5190 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Relationship between the appendix and ulcerative colitis: A new discovery
Manuscript Source Unsolicited Manuscript
All Author List Xu-Jia Wu, Reng-Yun Xiang, Pan Gong, Qian Chen and Xue-Feng Li
ORCID
Author(s) ORCID Number
Xu-Jia Wu http://orcid.org/0009-0007-3576-7892
Xue-Feng Li http://orcid.org/0009-0006-9806-4281
Funding Agency and Grant Number
Corresponding Author Xue-Feng Li, Chief Physician, PhD, Professor, Department of Gastroenterology, The First Affiliated Hospital of Jishou University, No. 108 Jian Xin Road, Jishou 416000, Hunan Province, China. longs9877@aliyun.com
Key Words Appendix; Ulcerative colitis; Inflammation; Immunity; Gut microbiota
Core Tip Investigating the relationship between the appendix and ulcerative colitis (UC) is crucial for understanding of UC pathogenesis. Appendectomy is superior to standard medical therapy alone in maintaining remission in patients with UC, suggesting that the appendix is a priming site for UC. Other studies have shown that appendectomy increases the risk of colorectal resection and colorectal cancer in UC. Therefore, further research is needed to establish whether the connection is clinically relevant. This review highlights the need for ongoing research to elucidate the complex relationship between the appendix and UC, providing valuable insights with significant promise for developing novel therapeutics.
Publish Date 2026-02-04 07:43
Citation

Wu XJ, Xiang RY, Gong P, Chen Q, Li XF. Relationship between the appendix and ulcerative colitis: A new discovery. World J Gastrointest Endosc 2026; 18(2): 113439

URL https://www.wjgnet.com/1948-5190/full/v18/i2/113439.htm
DOI https://dx.doi.org/10.4253/wjge.v18.i2.113439
Full Article (PDF) WJGE-18-113439-with-cover.pdf
Manuscript File 113439_Auto_Edited_015332.docx
Answering Reviewers 113439-answering-reviewers.pdf
Audio Core Tip 113439-audio.mp3
Conflict-of-Interest Disclosure Form 113439-conflict-of-interest-statement.pdf
Copyright License Agreement 113439-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 113439-non-native-speakers.pdf
Peer-review Report 113439-peer-reviews.pdf
Scientific Misconduct Check 113439-scientific-misconduct-check.png
Scientific Editor Work List 113439-scientific-editor-work-list.pdf
CrossCheck Report 113439-crosscheck-report.pdf