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Articles Published Processes
12/24/2025 9:56:54 AM | Browse: 1 | Download: 0
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Received |
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2025-08-26 02:12 |
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Peer-Review Started |
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2025-08-26 02:12 |
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First Decision by Editorial Office Director |
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2025-09-09 09:53 |
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Return for Revision |
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2025-09-09 09:53 |
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Revised |
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2025-09-18 15:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-11-25 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-25 13:01 |
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Articles in Press |
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2025-11-25 13:01 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-12 08:16 |
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Publish the Manuscript Online |
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2025-12-24 09:56 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Editorial |
| Article Title |
Reimagining risk stratification: Dipeptidyl peptidase 3 in the new era of cardiovascular biomarkers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Davide Ramoni, Luca Liberale, Federico Carbone and Fabrizio Montecucco |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Fabrizio Montecucco, MD, PhD, Professor, Department of Internal Medicine, University of Genoa, Viale Benedetto XV 6, Genoa 16132, Italy. fabrizio.montecucco@unige.it |
| Key Words |
Acute coronary syndrome; Cardiogenic shock; Dipeptidyl peptidase 3; Heart failure; Inflammation; Prognostic biomarkers; Renin–angiotensin–aldosterone system; Risk stratification; Therapeutic targeting |
| Core Tip |
Dipeptidyl peptidase 3 (DPP3) is a novel biomarker and active mediator in cardiovascular disease. Unlike traditional markers that simply reflect tissue injury, circulating DPP3 (cDPP3) directly influences hemodynamics by degrading angiotensin II and other vasoactive peptides, contributing to vasodilation, myocardial depression, and shock progression. Elevated cDPP3 predicts cardiogenic shock and mortality in acute coronary syndromes and heart failure, while its dynamic trajectory provides unique prognostic value. Beyond risk stratification, therapeutic neutralization of cDPP3 shows promise in reversing circulatory failure, positioning it at the interface of biomarker discovery and targeted intervention. |
| Publish Date |
2025-12-24 09:56 |
| Citation |
Ramoni D, Liberale L, Carbone F, Montecucco F. Reimagining risk stratification: Dipeptidyl peptidase 3 in the new era of cardiovascular biomarkers. World J Cardiol 2025; 17(12): 113443 |
| URL |
https://www.wjgnet.com/1949-8462/full/v17/i12/113443.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v17.i12.113443 |
© 2004-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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