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Articles Published Processes
3/6/2026 8:56:39 AM | Browse: 5 | Download: 15
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Received |
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2025-08-27 23:38 |
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Peer-Review Started |
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2025-08-27 23:38 |
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First Decision by Editorial Office Director |
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2025-09-17 08:22 |
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Return for Revision |
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2025-09-17 08:22 |
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Revised |
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2025-09-28 10:33 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-15 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-15 08:26 |
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Articles in Press |
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2025-12-15 08:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-29 10:49 |
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Publish the Manuscript Online |
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2026-03-06 08:56 |
| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pediatrics |
| Manuscript Type |
Prospective Study |
| Article Title |
Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Magd A Kotb, Manal M Wilson, Amani N Shafik, Noura A Ahmed, Veronia F Fahim, Nabil A Lotfi and Yasmin MR Eissawy |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Veronia F Fahim, PhD, Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Kasr El Ainy St., Kasr-Alainy, El Manial, Cairo 11956, Egypt. veronia.fawzy@kasralainy.edu.eg |
| Key Words |
Cytochrome P450 1A2; Neonatal cholestasis; Biliary atresia; Detoxification; Aflatoxins |
| Core Tip |
This study investigated cytochrome P450 1A2 (CYP1A2) detoxification enzyme levels in neonates with confirmed biliary atresia (BA), neonatal hepatitis and healthy infants. Significantly low serum CYP1A2 was frequent among BA and neonatal hepatitis patients compared to the control group. The synergism of null glutathione S-transferase and low serum CYP1A2 in BA; the Kotb disease maybe an additional factor that compromises the aflatoxins detoxification with subsequent acceleration of the progressive inflammatory adhesions and obliterative cholangiopathy early in life. Reduced CYP1A2 seems to be an inherent susceptibility to hepatitis in the neonatal period and may alter drugs’ pharmacokinetics. Careful consideration to drug dosing and toxicity risk should be given. |
| Publish Date |
2026-03-06 08:56 |
| Citation |
Kotb MA, Wilson MM, Shafik AN, Ahmed NA, Fahim VF, Lotfi NA, Eissawy YM. Neonatal cholestasis is associated with cytochrome P450 1A2 detoxification defect: A single center pilot study. World J Clin Pediatr 2026; 15(1): 113478 |
| URL |
https://www.wjgnet.com/2219-2808/full/v15/i1/113478.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v15.i1.113478 |
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