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Articles Published Processes
1/27/2026 10:12:33 AM | Browse: 84 | Download: 220
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Received |
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2025-08-28 00:09 |
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Peer-Review Started |
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2025-08-28 00:10 |
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First Decision by Editorial Office Director |
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2025-09-17 08:54 |
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2025-09-18 04:25 |
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Revised |
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2025-09-28 10:09 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-08 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-08 08:25 |
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Articles in Press |
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2025-12-08 08:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-13 03:42 |
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Publish the Manuscript Online |
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2026-01-27 10:12 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical spectrum and genotype-phenotype correlation of ABCB4 mutations in children: Insights from a North Indian cohort
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chennakeshava Thunga, Suvradeep Mitra, Alisha Babbar, Raghav Lal, Arnab Pal, Nandita Kakkar and Sadhna Bhasin Lal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sadhna Bhasin Lal, Head, Professor, Department of Paediatric Gastroenterology and Hepatology, Post Graduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. sadhnalal2014@gmail.com |
| Key Words |
ABCB4; Monoallelic mutation; Biallelic mutation; Progressive familial intrahepatic cholestasis type 3; Chronic liver disease; Decompensation; End-stage liver disease; Portal hypertension; Sclerosing cholangitis |
| Core Tip |
Patients with ABCB4 mutations continue to pose an enigma for clinicians, and understanding of the varied manifestations continues to evolve. Children with biallelic mutations had a progressive disease with ascites, larger varices and decompensation. Children with monoallelic mutations fare better with significantly better liver function in follow-up; however, the risk of disease progression and decompensation remains and needs close monitoring. Protein-truncating mutations and missense mutations in highly conserved domains are associated with early disease progression. Early genetic testing and family screening may help in tailoring treatment and prognostication. |
| Publish Date |
2026-01-27 10:12 |
| Citation |
Thunga C, Mitra S, Babbar A, Lal R, Pal A, Kakkar N, Lal SB. Clinical spectrum and genotype-phenotype correlation of ABCB4 mutations in children: Insights from a North Indian cohort. World J Hepatol 2026; 18(1): 113485 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i1/113485.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i1.113485 |
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