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Articles Published Processes
12/25/2025 8:27:16 AM | Browse: 5 | Download: 12
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Received |
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2025-08-27 10:12 |
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Peer-Review Started |
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2025-08-27 10:13 |
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First Decision by Editorial Office Director |
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2025-09-03 03:04 |
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Return for Revision |
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2025-09-03 03:04 |
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Revised |
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2025-09-15 06:39 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-10 02:33 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-10 05:53 |
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Articles in Press |
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2025-10-10 05:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-15 01:42 |
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Publish the Manuscript Online |
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2025-12-25 08:27 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Exploration of a new method of a biopatch based on the central concept of the multi-layer repair
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kai-Yue Guan, Qing-Zhen Wu, Bo Ning and En-Qiang Ling-Hu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Natural Science Foundation |
7234387 |
| Chinese PLA General Hospital Young Independent Innovation Science Foundation |
22QNFC004 |
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| Corresponding Author |
En-Qiang Ling-Hu, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Fuxing Road 28, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com |
| Key Words |
Gastric perforation; Omental patch; Surgery; Biopatch; Hydrogel |
| Core Tip |
We propose a novel “multi-layer repair” concept addressing the limitations of traditional omental patch repair for gastric ulcer perforation. Utilizing three-dimensional bioprinting technology, we engineered a biologically functional patch that recapitulates native gastric layering: An inner mucosal organoid-containing region and an outer smooth muscle cell layer. Preliminary results from animal studies indicated that this approach, which aimed to restore physiological structural-functional coupling of the stomach, appears to facilitate a repair that extends beyond mere mechanical closure, showing promise for achieving true anatomical and functional recovery. |
| Publish Date |
2025-12-25 08:27 |
| Citation |
Guan KY, Wu QZ, Ning B, Ling-Hu EQ. Exploration of a new method of a biopatch based on the central concept of the multi-layer repair. World J Gastrointest Surg 2025; 17(12): 113490 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i12/113490.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i12.113490 |
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