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Articles Published Processes
1/28/2026 9:23:38 AM | Browse: 2 | Download: 0
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Received |
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2025-08-28 01:56 |
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Peer-Review Started |
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2025-08-28 01:57 |
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First Decision by Editorial Office Director |
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2025-09-04 10:47 |
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Return for Revision |
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2025-09-04 10:47 |
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Revised |
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2025-09-18 21:09 |
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Publication Fee Transferred |
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2025-09-26 15:48 |
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Second Decision by Editor |
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2025-12-15 02:45 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-15 09:43 |
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Articles in Press |
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2025-12-15 09:43 |
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Edit the Manuscript by Language Editor |
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2025-12-22 05:08 |
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Typeset the Manuscript |
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2026-01-15 07:58 |
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Publish the Manuscript Online |
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2026-01-28 09:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Determination of correlation of clearance with clinical outcomes for inflammatory bowel disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Diane R Mould, Maximillian Kutschera, Christian Primas, Sieglinde Reinisch, Gottfried Novacek, Cornelia Lichtenberger, Thierry Dervieux, Yunju Bae, Sun Hee Lee, Joon Ho Lee and Walter Reinisch |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Diane R Mould, PhD, Projections Research Inc, 535 Springview Lane, Phoenixville, PA 19460, United States. drmould@pri-home.net |
| Key Words |
Antidrug antibodies; Bayesian model-guided dosing; Clearance; Inflammatory bowel disease; Infliximab; Pharmacokinetics; Therapeutic drug monitoring |
| Core Tip |
There have been several evaluations of the relationship between therapeutic antibody clearance and outcomes. Data from a large study in patients administered infliximab at labeled dose were used to assess probability of antidrug antibodies, C-reactive protein normalization, and mucosal healing based on baseline clearance. A compassionate use study further evaluated these correlations, and clearance often decreased from baseline due to individualized dosing, suggesting improvements in the probability of all outcomes. While this study is small, the results are encouraging and suggest that further research on the use of clearance as a therapeutic endpoint is warranted in this area. |
| Publish Date |
2026-01-28 09:23 |
| Citation |
Mould DR, Kutschera M, Primas C, Reinisch S, Novacek G, Lichtenberger C, Dervieux T, Bae Y, Lee SH, Lee JH, Reinisch W. Determination of correlation of clearance with clinical outcomes for inflammatory bowel disease. World J Gastroenterol 2026; 32(5): 113505 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i5/113505.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i5.113505 |
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