Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	11351
Country	Spain

Received	2014-05-18 16:48
Peer-Review Started	2014-05-18 23:38
To Make the First Decision	2014-06-18 18:39
Return for Revision	2014-06-19 10:00
Revised	2014-10-14 16:34
Second Decision	2014-11-10 15:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-11-10 16:17
Articles in Press	2014-11-10 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-07 20:33
Publish the Manuscript Online	2015-02-11 17:31

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pathogenesis of Crohn’s disease: Bug or no bug
Manuscript Source	Invited Manuscript
All Author List	Marta Maia Bosca-Watts, Joan Tosca, Rosario Anton, Maria Mora, Miguel Minguez and Francisco Mora
Funding Agency and Grant Number
Corresponding Author	Marta Maia Bosca-Watts, MD, IBD Unit, Digestive Disease Department, University of Valencia, University Clinic Hospital of Valencia and INCLIVA Health Research Institute, Avda. Blasco Ibañez 17, 46010 Valencia, Spain. inflamatoriahcuv@gmail.com
Key Words	Inflammatory bowel disease; Crohn’s dise­ase; Ulcerative colitis; Bacteria; Virus; Pathogenesis
Core Tip	The possibility of an infectious origin in inflammatory bowel disease (IBD) has been postulated since the first description of Crohn’s disease (CD). Many observations implicate bacteria as a trigger for the development of CD, and have tried to do so with virus. Inconclusive evidence relating IBD pathogenesis to Mycobacterium avium paratuberculosis, salmonella, campylobacter, etc., has been found. The tendency now under discussion to regard microbiota as the primary catalyst, has led to the latest studies on microbiota as pathogens, focusing on Escherichia coli, mainly in ileal CD. The present review discusses the literature available on these “bugs”.
Publish Date	2015-02-11 17:31
Citation	Bosca-Watts MM, Tosca J, Anton R, Mora M, Minguez M, Mora F. Pathogenesis of Crohn’s disease: Bug or no bug. World J Gastrointest Pathophysiol 2015; 6(1): 1-12
URL	http://www.wjgnet.com/2150-5330/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.4291/wjgp.v6.i1.1

Manuscript File	11351-Review.doc
Answering Reviewers	11351-Answering reviewers.pdf
Copyright License Agreement	11351-Copyright assignment.pdf
Peer-review Report	11351-Peer review(s).pdf
Scientific Misconduct Check	11351-CrossCheck.jpg
Scientific Editor Work List	11351-Scientific editor work list.pdf