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Articles Published Processes
12/11/2025 8:20:59 AM | Browse: 175 | Download: 444
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Received |
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2025-08-28 00:29 |
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Peer-Review Started |
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2025-08-28 00:29 |
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First Decision by Editorial Office Director |
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2025-09-16 07:48 |
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Return for Revision |
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2025-09-16 07:48 |
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Revised |
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2025-09-17 15:04 |
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Publication Fee Transferred |
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2025-09-21 06:28 |
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Second Decision by Editor |
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2025-11-06 02:48 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-06 08:43 |
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Articles in Press |
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2025-11-06 08:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-12-02 01:48 |
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Publish the Manuscript Online |
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2025-12-11 08:20 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Exosomal miR-191 promotes colorectal cancer progression by inducing M2 macrophage polarization and inhibiting ferroptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qing-Yun Zhao and Shou-Jiang Wei |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shou-Jiang Wei, Professor, Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, No. 1 Maoyuan Road, Shunqing District, Nanchong 637000, Sichuan Province, China. nsmcwsj@163.com |
| Key Words |
Colorectal cancer; MiR-191; Exosome; Macrophages; Ferroptosis; M2 polarization |
| Core Tip |
We successfully isolated exosomes from colorectal cancer (CRC) cells. Inhibition of miR-191 in CRC cells suppressed M2 polarization of macrophages. After coculture of macrophages, inhibition of miR-191 induced reactive oxygen species production, ferroptosis, and apoptosis of CRC cells. Silencing of exosomal miR-191 from CRC cells prevented M2 polarization of macrophages, and weakened CRC development by inducing ferroptosis in macrophages. Exosomal miR-191 also accelerated cancer progression in CRC nude mice by promoting M2 polarization of macrophages. |
| Publish Date |
2025-12-11 08:20 |
| Citation |
Zhao QY, Wei SJ. Exosomal miR-191 promotes colorectal cancer progression by inducing M2 macrophage polarization and inhibiting ferroptosis. World J Gastrointest Oncol 2025; 17(12): 113524 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i12/113524.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i12.113524 |
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