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Articles Published Processes
2/26/2026 10:19:31 AM | Browse: 5 | Download: 1
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Received |
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2025-09-23 09:02 |
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Peer-Review Started |
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2025-09-23 09:02 |
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First Decision by Editorial Office Director |
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2025-10-17 03:48 |
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Return for Revision |
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2025-10-17 03:48 |
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Revised |
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2025-11-04 14:04 |
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Publication Fee Transferred |
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2025-11-12 07:33 |
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Second Decision by Editor |
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2025-12-11 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-11 06:26 |
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Articles in Press |
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2025-12-11 06:26 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-05 03:30 |
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Publish the Manuscript Online |
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2026-02-26 10:19 |
| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Spatial immune cell architecture after gastric cancer surgery predicts prognosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Heng-Jin Yang and Ben Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ben Liu, Department of Oncology, Shuyang County Hospital of Traditional Chinese Medicine, No. 28 Middle Shanghai Road, Shucheng Street, Suqian 223600, Jiangsu Province, China. liuben5723@163.com |
| Key Words |
Correlation analysis; Immune cell infiltration; Tumor microenvironment; Gastric cancer; Over survival |
| Core Tip |
This retrospective cohort study evaluated spatial distribution patterns of immune cells in the tumor microenvironment after radical gastrectomy for gastric cancer using multiplex immunohistochemistry. High CD8+ T-cell density at the invasive margin, a CD8+/forkhead box protein 3+ ratio > 2.5, and low programmed death ligand 1+ tumor cell proportion were independent predictors of favorable survival. An immune prognostic score integrating these features achieved high accuracy in predicting 5-year overall survival. These findings highlight the prognostic value of immune cell spatial profiling and may guide individualized postoperative immunotherapy strategies. |
| Publish Date |
2026-02-26 10:19 |
| Citation |
Yang HJ, Liu B. Spatial immune cell architecture after gastric cancer surgery predicts prognosis. World J Gastrointest Surg 2026; 18(2): 113530 |
| URL |
https://www.wjgnet.com/1948-9366/full/v18/i2/113530.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v18.i2.113530 |
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