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Articles Published Processes
2/12/2026 11:20:20 AM | Browse: 67 | Download: 242
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Received |
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2025-08-28 15:08 |
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Peer-Review Started |
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2025-08-29 00:19 |
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First Decision by Editorial Office Director |
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2025-09-23 08:20 |
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Return for Revision |
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2025-09-23 08:20 |
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Revised |
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2025-10-18 19:54 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-08 02:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-08 08:27 |
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Articles in Press |
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2025-12-08 08:27 |
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Edit the Manuscript by Language Editor |
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2025-12-12 23:13 |
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Typeset the Manuscript |
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2026-02-04 00:36 |
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Publish the Manuscript Online |
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2026-02-12 11:20 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Dynamic inflammation-based prognostication in acute-on-chronic liver failure: The COSSH-CAR model as a step forward in personalized risk stratification
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Noura A A Ebrahim, Thoraya A Farghaly and Soliman M A Soliman |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Noura A A Ebrahim, MD, PhD, Department of Oncologic Pathology, National Cancer Institute, Cairo University, Kasr Al Eini Street, Fom El Khalig, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com |
| Key Words |
Acute-on-chronic liver failure; C-reactive protein to albumin ratio; COSSH-CAR; Dynamic biomarkers; Systemic inflammation; Hepatic encephalopathy; Risk stratification |
| Core Tip |
The dynamic shift in the C-reactive protein to albumin ratio during the initial week provides additional prognostic insight into Chinese Group on Study of Severe Hepatitis B-defined acute-on-chronic liver failure, surpassing the predictive capacity of traditional indices such as the model for end-stage liver disease sodium score and hepatic encephalopathy grade. Embedding 7-day variation of CAR within the Chinese Group on Study of Severe Hepatitis B-C-reactive protein to albumin ratio score yields a biologically plausible, practical bedside instrument. Nonetheless, confirmation through robust, multicenter validation is essential before widespread clinical application can be recommended. |
| Publish Date |
2026-02-12 11:20 |
| Citation |
Ebrahim NAA, Farghaly TA, Soliman SMA. Dynamic inflammation-based prognostication in acute-on-chronic liver failure: The COSSH-CAR model as a step forward in personalized risk stratification. World J Hepatol 2026; 18(2): 113552 |
| URL |
https://www.wjgnet.com/1948-5182/full/v18/i2/113552.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v18.i2.113552 |
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