Publication Name	World Journal of Gastroenterology
Manuscript ID	11356
Country	South Korea

Received	2014-05-17 11:46
Peer-Review Started	2014-05-17 17:49
To Make the First Decision	2014-06-10 13:31
Return for Revision	2014-06-12 21:05
Revised	2014-06-27 10:47
Second Decision	2014-07-30 10:08
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-30 10:24
Articles in Press	2014-07-30 10:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 10:44
Publish the Manuscript Online	2014-12-10 15:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice
Manuscript Source	Unsolicited Manuscript
All Author List	Mi Na Kim, Seong-Joon Koh, Jung Mogg Kim, Jong Pil Im, Hyun Chae Jung and Joo Sung Kim
Funding Agency and Grant Number
Corresponding Author	Joo Sung Kim, MD, PhD, Department of Internal Medicine, Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Chongno-gu, Seoul 110-744, South Korea. jooskim@snu.ac.kr
Key Words	Clostridium difficile; Inflammatory bowel disease; Interleukin 10-deficient mice; Interferon-; Colitis
Core Tip	The results of this study indicate that Clostridium difficile (C. difficile) infection induces more severe colitis in the interleukin 10-deficient (IL-10-/-) mouse model of inflammatory bowel disease (IBD). Moreover, induction of interferon-? gene expression was greater in the IL-10-/- mice and their bone marrow-derived dendritic cells compared to wild type mice following C. difficile infection and exposure to C. difficile toxin A, respectively. This study demonstrates the establishment of C. difficile-aggravated colitis in an IBD animal model, which provides a useful tool for studying the relationship between C. difficile and host immune response of the gut in IBD.
Publish Date	2014-12-10 15:52
Citation	Kim MN, Koh SJ, Kim JM, Im JP, Jung HC, Kim JS. Clostridium difficile infection aggravates colitis in interleukin 10-deficient mice. World J Gastroenterol 2014; 20(45): 17084-17091
URL	http://www.wjgnet.com/1007-9327/full/v20/i45/17084.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i45.17084

Full Article (PDF)	WJG-20-17084.pdf
Full Article (Word)	WJG-20-17084.doc
Manuscript File	11356-Review.docx
Answering Reviewers	11356-Answering reviewers.pdf
Copyright License Agreement	11356-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	11356-Language certificate.pdf
Peer-review Report	11356-Peer review.pdf
Scientific Misconduct Check	11356-CorssCheck.jpg
Scientific Editor Work List	11356-Scientific editor work list.pdf