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12/11/2025 8:20:54 AM | Browse: 2 | Download: 1
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 113598
Country United States
Received
2025-08-29 03:28
Peer-Review Started
2025-08-29 03:28
First Decision by Editorial Office Director
2025-09-16 07:49
Return for Revision
2025-09-16 07:49
Revised
2025-09-17 14:17
Publication Fee Transferred
Second Decision by Editor
2025-10-22 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-22 08:52
Articles in Press
2025-10-22 08:52
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-12-02 01:50
Publish the Manuscript Online
2025-12-11 08:20
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Letter to the Editor
Article Title Combining irreversible electroporation and immunotherapy for hepatocellular carcinoma: Reflections and directions for advancement
Manuscript Source Invited Manuscript
All Author List Arunkumar Krishnan and Diptasree Mukherjee
ORCID
Author(s) ORCID Number
Arunkumar Krishnan http://orcid.org/0000-0002-9452-7377
Diptasree Mukherjee http://orcid.org/0000-0002-8962-2759
Funding Agency and Grant Number
Corresponding Author Arunkumar Krishnan, Department of Oncology, Atrium Health Levine Cancer, 1021 Morehead Medical Drive, Suite 70100, Charlotte, NC 28204, United States. dr.arunkumar.krishnan@gmail.com
Key Words Irreversible electroporation; Anti-programmed death-1 therapy; Hepatocellular carcinoma; Tumor immunology; Immune checkpoint blockade; Murine cancer model; Translational oncology
Core Tip A recent study by Xing et al explored how combining a special tumor treatment called irreversible electroporation with a type of immunotherapy (anti-programmed death-1) can help the immune system fight liver cancer in mice. While the results are promising, the study requires clearer explanations of how and where samples were collected, more effective use of statistical methods, and a cautious interpretation of the findings. Future studies should use models more similar to human liver cancer and test long-term effects and safety to understand the treatment’s potential for patients.
Publish Date 2025-12-11 08:20
Citation

Krishnan A, Mukherjee D. Combining irreversible electroporation and immunotherapy for hepatocellular carcinoma: Reflections and directions for advancement. World J Gastrointest Oncol 2025; 17(12): 113598

URL https://www.wjgnet.com/1948-5204/full/v17/i12/113598.htm
DOI https://dx.doi.org/10.4251/wjgo.v17.i12.113598
Full Article (PDF) WJGO-17-113598-with-cover.pdf
Manuscript File 113598_Auto_Edited_022850.docx
Answering Reviewers 113598-answering-reviewers.pdf
Audio Core Tip 113598-audio.mp3
Conflict-of-Interest Disclosure Form 113598-conflict-of-interest-statement.pdf
Copyright License Agreement 113598-copyright-assignment.pdf
Peer-review Report 113598-peer-reviews.pdf
Scientific Misconduct Check 113598-scientific-misconduct-check.png
Scientific Editor Work List 113598-scientific-editor-work-list.pdf
CrossCheck Report 113598-crosscheck-report.pdf