| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Nobue Futawatari, Takashi Fukuyama, Yusuke Akimoto, Junji Maehara, Daisuke Hihara, Yosuke Okamoto, Yuki Yokouchi, Kei Takahashi, Manabu Watanabe and Yoshihisa Saida |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Takashi Fukuyama, PhD, Division of Biomedical Research, Kitasato University Medical Center, Arai 6-100, Kitamoto 364-8501, Saitama, Japan. fukuyam@insti.kitasato-u.ac.jp |
| Key Words |
Gastric cancer; Kita-Kyushu lung cancer antigen-1; Multiple cancers; Prognostic marker; Tumor differentiation |
| Core Tip |
We have previously reported that the cancer/testis antigen Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is frequently expressed in gastric cancer (GC), with high expression observed in multiple GCs. Therefore, as a preliminary study, we investigated the relationship between KK-LC-1 expression and multiple GCs, focusing on its potential clinical utility. In the middle and lower stomach regions, KK-LC-1 expression was significantly associated with older age, differentiated histological type, and the presence of multiple cancers, with all cases in the multiple cancer group exhibiting KK-LC-1 positivity (100%). KK-LC-1 expression in primary gastric tumors suggests a higher risk of subsequent development of multiple GCs. |
| Publish Date |
2026-01-20 09:06 |
| Citation |
Futawatari N, Fukuyama T, Akimoto Y, Maehara J, Hihara D, Okamoto Y, Yokouchi Y, Takahashi K, Watanabe M, Saida Y. Kita-Kyushu lung cancer antigen-1 expression in initial gastric tumors predicts multiple cancer development: A pilot study. World J Clin Oncol 2026; 17(1): 113612 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i1/113612.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i1.113612 |
