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Articles Published Processes
11/26/2025 3:57:04 AM | Browse: 0 | Download: 0
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Received |
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2025-08-31 05:59 |
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Peer-Review Started |
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2025-08-31 05:59 |
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To Make the First Decision |
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Return for Revision |
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2025-09-12 06:58 |
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Revised |
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2025-09-25 11:27 |
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Second Decision |
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2025-11-05 02:47 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-11-05 08:40 |
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Articles in Press |
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2025-11-05 08:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-19 01:17 |
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Publish the Manuscript Online |
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2025-11-26 03:57 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Application of stem cell-derived exosomes in bone and joint diseases: Recent advances enabled by diverse carrier technologies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ya-Jun Fu, Jie Jian, Can Liu, Yang-Fei Yi, Yi-Tong Ding, Jie Wen, Yu-Fei Li and Qing-Jun Guo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science Project of Hunan Provincial Healthy Commission |
20230844 |
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| Corresponding Author |
Jie Wen, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 Jiefang West Road, Changsha 410013, Hunan Province, China. cashwj@qq.com |
| Key Words |
Bone and joint diseases; Osteoarthritis; Stem cell-derived exosomes; Delivery systems; Biomaterial scaffolds |
| Core Tip |
Bone and joint diseases, such as osteoarthritis, exhibit significant pathological complexity. Current treatment modalities possess notable limitations, driving the development of cell-free regenerative treatment strategies centered on stem cell-derived exosomes, particularly mesenchymal stem cell-derived exosomes. Despite the promise of mesenchymal stem cell-derived exosomes, several challenges impede their clinical translation. In recent years, optimizing exosome functionality and achieving precise delivery through carrier technologies has emerged as a pivotal strategy to overcome these barriers. This review systematically evaluates the latest advancements in cutting-edge carrier technologies. Looking ahead, multimodal delivery systems integrating gene editing, intelligent responsive materials, and personalized treatment strategies are expected to revolutionize bone and joint disease treatment by transitioning from symptom alleviation to functional reconstruction. |
| Publish Date |
2025-11-26 03:57 |
| Citation |
<p>Fu YJ, Jian J, Liu C, Yi YF, Ding YT, Wen J, Li YF, Guo QJ. Application of stem cell-derived exosomes in bone and joint diseases: Recent advances enabled by diverse carrier technologies. <i>World J Stem Cells</i> 2025; 17(11): 113631</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i11/113631.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i11.113631 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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