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1/22/2026 8:14:06 AM | Browse: 0 | Download: 0
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Received |
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2025-09-01 08:55 |
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Peer-Review Started |
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2025-09-01 08:57 |
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First Decision by Editorial Office Director |
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2025-10-11 06:53 |
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Return for Revision |
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2025-10-11 06:53 |
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Revised |
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2025-10-24 06:21 |
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Publication Fee Transferred |
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2025-10-27 13:07 |
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Second Decision by Editor |
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2025-11-19 02:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-11-19 09:27 |
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Articles in Press |
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2025-11-19 09:27 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-15 01:15 |
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Publish the Manuscript Online |
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2026-01-22 08:14 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Gao, Kang-Peng Zhong, Jun-Zhuo Wang, Yi Chen and Chun-Xiao Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province |
No. LQ22H030001 |
| Natural Science Foundation of Ningbo |
No. 2024J474 |
| Ningbo Top Medical and Health Research Program |
No. 2023020612 |
| Project of Ningbo Leading Medical and Healthy Discipline |
No. 2022-S04 |
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| Corresponding Author |
Chun-Xiao Li, PhD, Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo 315010, Zhejiang Province, China. 11418130@zju.edu.cn |
| Key Words |
Allyl isothiocyanate; Metabolic dysfunction-associated steatotic liver disease; Vitamin D receptor; Fatty acid β-oxidation; Lipid synthesis |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) denotes a continuum of disorders unified by hepatic steatosis and can affect approximately one quarter of the global population, reaching up to 75% among individuals with obesity. This work seeks to define the functional contribution and mechanism of allyl isothiocyanate (AITC) in mitigating MASLD via the vitamin D receptor (VDR). In an in vitro MASLD model, AITC activates VDR through hepatocyte nuclear factor 4 alpha/microsomal triglyceride transfer protein/apolipoprotein B signaling, thereby reducing lipid accumulation and insulin resistance while promoting fatty acid β-oxidation. Taken together, these results show the therapeutic promise of AITC in MASLD. |
| Publish Date |
2026-01-22 08:14 |
| Citation |
Gao T, Zhong KP, Wang JZ, Chen Y, Li CX. Allyl isothiocyanate ameliorates metabolic dysfunction-associated steatotic liver disease via vitamin D receptors in hepatocytes. World J Gastroenterol 2026; 32(4): 113647 |
| URL |
https://www.wjgnet.com/1007-9327/full/v32/i4/113647.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v32.i4.113647 |
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