| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhe Cheng, Yi-Fan Lu, Yi-Xian He, Wei Wei, Yi-Xuan Xie, Tian-Su Lv, Yi Wei, Yan Lou, Jiang-Yi Yu and Xi-Qiao Zhou |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jiangsu Postgraduate Research and Practice Innovation Programme |
KYCX24_2242 |
| Science and Technology Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine |
Y22002 |
| Forth Batch of Construction Program for Inheritance Office of Jiangsu Province Famous Traditional Chinese Medicine Experts |
[2021]7 |
|
| Corresponding Author |
Xi-Qiao Zhou, Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Qinhuai District, Nanjing, Nanjing 210000, Jiangsu Province, China. zhouxiqiao@njucm.edu.cn |
| Key Words |
Xietu Hemu prescription; Metabolic dysfunction-associated steatotic liver disease; Obesity; Lipotoxicity; Leptin |
| Core Tip |
Xietu Hemu prescription, a traditional Chinese medicine formula, ameliorates metabolic dysfunction-associated steatotic liver disease-related obesity by inhibiting adipogenesis. Integrating serum metabolomics, transcriptomics, and network analysis, this study identified the LEP/AMPK/PPARγ signaling axis as the central mechanism. The formula promotes leptin autocrine secretion, activates AMPK phosphorylation, and subsequently downregulates PPARγ and SREBPs, thereby reducing lipid accumulation and improving metabolic homeostasis, offering a novel multi-target therapeutic strategy. |
| Publish Date |
2025-12-26 10:27 |
| Citation |
Cheng Z, Lu YF, He YX, Wei W, Xie YX, Lv TS, Wei Y, Lou Y, Yu JY, Zhou XQ. Integrated serum metabolomics reveal molecular mechanism of Xietu Hemu prescription on metabolic dysfunction-associated steatotic liver disease-related obesity. World J Hepatol 2025; 17(12): 113660 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i12/113660.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i12.113660 |
