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Articles Published Processes
2/3/2026 6:28:05 AM | Browse: 3 | Download: 12
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Received |
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2025-09-01 11:11 |
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Peer-Review Started |
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2025-09-01 11:12 |
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First Decision by Editorial Office Director |
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2025-10-11 06:54 |
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Return for Revision |
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2025-10-11 07:42 |
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Revised |
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2025-11-03 20:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-12-09 02:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-10 06:50 |
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Articles in Press |
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2025-12-10 06:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-01-26 15:45 |
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Publish the Manuscript Online |
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2026-02-03 06:28 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Serum protein induced by vitamin K absence or antagonist-II predicts aggressive tumor biology in alpha-fetoprotein-normal hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zaigham Abbas, Darayus P Gazder, Zeeshan Hyder, Muhammad Ali Qadeer and Minaam Abbas |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zaigham Abbas, AGAF, FACG, FACP, FRCP, Head, Professor, Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, 4/B Shahrah-e-Ghalib, Block 6, Clifton, Karachi 75600, Sindh, Pakistan. drzabbas@gmail.com |
| Key Words |
Alpha fetoprotein; Protein induced by vitamin K absence/antagonist-II; Des-gamma carboxy prothrombin; Hepatocellular carcinoma; Biomarkers; Aggressive tumor |
| Core Tip |
Alpha-fetoprotein (AFP) often underperforms as a biomarker for hepatocellular carcinoma (HCC). Our study shows that protein induced by vitamin K absence/antagonist-II (PIVKA-II) better indicates aggressive disease when AFP is normal. In normal AFP HCC, PIVKA-II ≥ 400 mAU/mL is linked to high-risk features, and ≥ 4000 mAU/mL identifies an especially aggressive group. Using PIVKA-II in surveillance and treatment planning could improve early detection and outcomes, particularly for AFP-negative patients. Transplant choices may change: Low PIVKA-II, even with large tumors, may suggest slower disease, while very high PIVKA-II within size limits signals higher post-transplant recurrence risk. These findings support updating HCC management guidelines and practice. |
| Publish Date |
2026-02-03 06:28 |
| Citation |
Abbas Z, Gazder DP, Hyder Z, Qadeer MA, Abbas M. Serum protein induced by vitamin K absence or antagonist-II predicts aggressive tumor biology in alpha-fetoprotein-normal hepatocellular carcinoma. World J Gastrointest Oncol 2026; 18(2): 113673 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i2/113673.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i2.113673 |
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