| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jia-Yu Pang, Rong-Yao Jin, Han-Xiao Zhang, Ying-Hua Zhang, Xin-Yue Wei, Wen-Bo Cao, Yi-Xiao Chen, Jun-Ling Wang and Sai-Jun Mo |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation of Henan Educational Committee |
26A310017 |
| College Student Innovation and Entrepreneurship Competitions |
S202510459221, 2025cxcy639 |
| Natural Science Foundation of Henan |
242300421493 |
| the Medical Science and Technology Planning Project of Henan Province |
LHGJ20220525 |
|
| Corresponding Author |
Sai-Jun Mo, Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. sjmo@zzu.edu.cn |
| Key Words |
Digestive tract tumors; Perineural invasion; Immune system; Tumor microenvironment; Immunotherapy |
| Core Tip |
Digestive tract tumors remain a major global health burden with high morbidity and mortality. Perineural invasion (PNI), the infiltration of tumor cells along nerves, is a key determinant of tumor aggressiveness and poor outcome. This review systematically investigates the crosstalk between PNI and immune mechanisms in gastrointestinal cancers, with a focus on critical components, including the PD-L1/PD-1 axis, T cells, macrophages, and other immune checkpoints. It reveals mechanisms by which PNI reshapes the tumor immune microenvironment to promote metastasis, identify candidate immunotherapeutic targets, and provide a foundation for developing precision treatment strategies. |
| Publish Date |
2026-02-06 06:30 |
| Citation |
Pang JY, Jin RY, Zhang HX, Zhang YH, Wei XY, Cao WB, Chen YX, Wang JL, Mo SJ. Perineural invasion in digestive tract tumors: Immune system interactions and therapeutic strategies. World J Clin Oncol 2026; 17(2): 113674 |
| URL |
https://www.wjgnet.com/2218-4333/full/v17/i2/113674.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v17.i2.113674 |
