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Articles Published Processes
2/14/2026 6:34:06 AM | Browse: 1 | Download: 28
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Received |
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2025-09-02 06:31 |
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Peer-Review Started |
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2025-09-02 06:32 |
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First Decision by Editorial Office Director |
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2025-09-30 08:00 |
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Return for Revision |
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2025-09-30 08:00 |
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Revised |
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2025-10-13 11:06 |
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Publication Fee Transferred |
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2025-10-17 13:44 |
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Second Decision by Editor |
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2025-12-15 02:47 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-12-22 09:43 |
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Articles in Press |
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2025-12-22 09:43 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2026-02-04 02:26 |
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Publish the Manuscript Online |
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2026-02-14 06:34 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Daniyaer Dilimulati, Diyaer Dilimulati and Lei Cui |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lei Cui, /, Shanghai Tenth People’s Hospital, No. 1239 Siping Road, Shanghai 200072, China. 14209@tongji.edu.cn |
| Key Words |
Adipose-derived stem cells; Alpha-ketoglutarate; Hypoxia-inducible factor 1-alpha; Redox homeostasis; Glycogen metabolism; Wound healing; Oxidative stress |
| Core Tip |
This study reveals that preconditioning adipose-derived stem cells with α-ketoglutarate enhances their survival in burn wounds through hypoxia-inducible factor 1α-mediated dual metabolic adaptations. Hypoxia-inducible factor 1α activation simultaneously promotes glutamine metabolism for antioxidant glutathione synthesis and enhances glycogen storage for energy maintenance under stress. This metabolic reprogramming strategy significantly improves cell viability and wound healing efficacy, offering a novel approach to enhance stem cell-based therapies in regenerative medicine. |
| Publish Date |
2026-02-14 06:34 |
| Citation |
Dilimulati D, Dilimulati D, Cui L. Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics. World J Stem Cells 2026; 18(2): 113694 |
| URL |
https://www.wjgnet.com/1948-0210/full/v18/i2/113694.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v18.i2.113694 |
© 1993-2026 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
