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4/29/2026 8:51:28 AM | Browse: 1 | Download: 0
Publication Name World Journal of Psychiatry
Manuscript ID 113723
Country China
Received
2025-09-02 06:12
Peer-Review Started
2025-09-02 06:12
First Decision by Editorial Office Director
2025-11-06 08:27
Return for Revision
2025-11-06 08:27
Revised
2025-12-16 13:48
Publication Fee Transferred
2025-12-29 10:17
Second Decision by Editor
2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2026-02-09 06:27
Articles in Press
2026-02-09 06:27
Edit the Manuscript by Language Editor
2026-02-18 12:32
Typeset the Manuscript
2026-04-16 03:08
Publish the Manuscript Online
2026-04-29 08:51
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Case Report
Article Title Hypertension induced by sudden clozapine withdrawal in a schizophrenia patient with metabolic syndrome: A case report
Manuscript Source Unsolicited Manuscript
All Author List Ji-Zhou Liu, Ting Ma, Zi-Yan Liang, Xuan-Bo Ning, Wang-Jin Li, Jian-Ping Wang, Yan-Li Jin, Ning Zhou and Jin-Feng Li
ORCID
Author(s) ORCID Number
Ji-Zhou Liu http://orcid.org/0009-0008-9856-9161
Funding Agency and Grant Number
Corresponding Author Jin-Feng Li, Department of Psychiatry, Hospital for Infectious Diseases, Dongfanghong Farm, Yuguopu Subdistrict, Mengzi 661002, Honghe Hani and Yi Autonomous Prefecture, China. 17145353@qq.com
Key Words Schizophrenia; Metabolic syndrome; Clozapine withdrawal; Hypertension; Case report
Core Tip This case is the first to describe severe, refractory hypertension as a consequence of sudden clozapine withdrawal in a patient with treatment-resistant schizophrenia and metabolic syndrome. Blood pressure remained uncontrolled despite intensive antihypertensive therapy, while normalized rapidly after clozapine reintroduction. These findings demonstrate that hypertension may be an unrecognized manifestation of clozapine withdrawal and highlight the critical importance of vigilant blood pressure monitoring, gradual tapering, and, when necessary, reintroduction of clozapine. This report contributes to the understanding of clozapine withdrawal syndromes and provides valuable clinical guidance for the safe management of affected patients.
Publish Date 2026-04-29 08:51
Citation

Liu JZ, Ma T, Liang ZY, Ning XB, Li WJ, Wang JP, Jin YL, Zhou N, Li JF. Hypertension induced by sudden clozapine withdrawal in a schizophrenia patient with metabolic syndrome: A case report. World J Psychiatry 2026; 16(5): 113723

URL https://www.wjgnet.com/2220-3206/full/v16/i5/113723.htm
DOI https://dx.doi.org/10.5498/wjp.v16.i5.113723
Full Article (PDF) WJP-16-113723-with-cover.pdf
CARE Checklist–2016 113723-CARE-Checklist-2016.pdf
Manuscript File 113723_Auto_Edited_033415.docx
Answering Reviewers 113723-answering-reviewers.pdf
Audio Core Tip 113723-audio.mp3
Conflict-of-Interest Disclosure Form 113723-conflict-of-interest-statement.pdf
Copyright License Agreement 113723-copyright-assignment.pdf
Signed Consent for Treatment Form(s) or Document(s) 113723-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate 113723-non-native-speakers.pdf
Peer-review Report 113723-peer-reviews.pdf
Scientific Misconduct Check 113723-scientific-misconduct-check.png
Scientific Editor Work List 113723-scientific-editor-work-list.pdf
CrossCheck Report 113723-crosscheck-report.pdf