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11/27/2025 7:53:58 AM | Browse: 11 | Download: 22
Publication Name World Journal of Hepatology
Manuscript ID 113756
Country United States
Received
2025-09-02 04:53
Peer-Review Started
2025-09-02 04:53
First Decision by Editorial Office Director
2025-10-13 08:51
Return for Revision
2025-10-13 08:51
Revised
2025-10-25 19:41
Publication Fee Transferred
Second Decision by Editor
2025-10-30 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-10-30 05:34
Articles in Press
2025-10-30 05:34
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-11-17 05:41
Publish the Manuscript Online
2025-11-27 07:53
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Roles of short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis
Manuscript Source Invited Manuscript
All Author List Chun-Ye Zhang, Shuai Liu, Yu-Xiang Sui and Ming Yang
ORCID
Author(s) ORCID Number
Chun-Ye Zhang http://orcid.org/0000-0003-2567-029X
Ming Yang http://orcid.org/0000-0002-4895-5864
Funding Agency and Grant Number
Corresponding Author Ming Yang, Assistant Professor, PhD, Department of Surgery, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, United States. minyang@uchc.edu
Key Words Short-chain fatty acids; Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Inflammation; Immune response; Metabolism
Core Tip Short-chain fatty acids (SCFAs) produced by gut microbial fermentation of indigestible fiber play important roles in regulating liver inflammation, fibrosis, and energy metabolism. The common SCFAs in the gut and liver are acetate, butyrate, and propionate. Strategies that enhance SCFA production, such as probiotic or dietary fiber supplementation, bariatric surgery, ketohexokinase inhibition, or fecal microbiota transplantation, offer promising methods for preventing metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis.
Publish Date 2025-11-27 07:53
Citation

Zhang CY, Liu S, Sui YX, Yang M. Roles of short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis. World J Hepatol 2025; 17(11): 113756

URL https://www.wjgnet.com/1948-5182/full/v17/i11/113756.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i11.113756
Full Article (PDF) WJH-17-113756-with-cover.pdf
Manuscript File 113756_Auto_Edited_011053.docx
Answering Reviewers 113756-answering-reviewers.pdf
Audio Core Tip 113756-audio.mp3
Conflict-of-Interest Disclosure Form 113756-conflict-of-interest-statement.pdf
Copyright License Agreement 113756-copyright-assignment.pdf
Supplementary Material 113756-supplementary-material.pdf
Peer-review Report 113756-peer-reviews.pdf
Scientific Misconduct Check 113756-scientific-misconduct-check.png
Scientific Editor Work List 113756-scientific-editor-work-list.pdf
CrossCheck Report 113756-crosscheck-report.pdf