| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Comprehensive modeling of the Correa cascade in precancerous lesions of gastric cancer: Leveraging animal, cellular, and organoid systems for translational insights
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Jie Zhou, Xin-Yu Hao, Chen Wang, Ning-Ning Ren and Yan-Gang Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82575015 |
| Beijing Natural Science Foundation |
7232281 |
| Fundamental Research Funds for the Central Universities |
2025-JYB-JBGS-001 |
|
| Corresponding Author |
Ning-Ning Ren, PhD, Department of Spleen and Stomach, Beijing University of Chinese Medicine Third Affiliated Hospital, No. 11 North Third Ring East Road, Chaoyang District, Beijing 100029, China. renning2024@163.com |
| Key Words |
Precancerous lesions of gastric cancer; Correa cascade; Animal model; Cellular model; Organoid; Helicobacter pylori; Tumor microenvironment; Translational research |
| Core Tip |
Precancerous lesions of gastric cancer (GC), including atrophic gastritis, intestinal metaplasia, and dysplasia, represent the pivotal transition in the Correa cascade. Accurate modeling of these lesions is crucial for dissecting early gastric tumorigenesis and identifying chemopreventive strategies. This scoping study systematically summarizes current precancerous lesions of GC models, including chemical- and infection-induced animal systems, transformed gastric epithelial cell lines, and organoid platforms derived from stem cells. We highlight their advantages, limitations, and recent advances such as genome editing, single-cell technologies, and immune co-culture. These insights provide a roadmap for selecting appropriate experimental systems and accelerating translational research in early GC prevention and therapy. |
| Publish Date |
2026-03-12 12:25 |
| Citation |
Zhou LJ, Hao XY, Wang C, Ren NN, Wang YG. Comprehensive modeling of the Correa cascade in precancerous lesions of gastric cancer: Leveraging animal, cellular, and organoid systems for translational insights. World J Gastrointest Oncol 2026; 18(3): 113757 |
| URL |
https://www.wjgnet.com/1948-5204/full/v18/i3/113757.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v18.i3.113757 |
